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HLA and Non-HLA Factors for Donor Selection in Hematopoietic Stem Cell Transplantation with Post-Transplant Cyclophosphamide GvHD Prophylaxis.
Cells
December 2024
Cleveland Clinic, Allogen, Pathology & Laboratory Medicine Institute, Cleveland, OH 44195, USA.
Human leukocyte antigen (HLA) mismatches in stem cell transplantation can be well-tolerated with the use of post-transplant cyclophosphamide (PTCy) for graft-versus-host-disease (GvHD) prophylaxis. Haploidentical (Haplo) and HLA-mismatched unrelated donors become acceptable donors. This review focuses on Haplo and unrelated donor selection in the context of PTCy-transplant for hematological malignancy, in comparison with conventional GvHD prophylaxis.
View Article and Find Full Text PDFParenthood in a Swedish prospective cohort of 1,378 adolescents and young adults banking semen for fertility preservation at time of cancer diagnosis.
Front Endocrinol (Lausanne)
December 2024
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Background: The possibility of future parenthood is a highly relevant issue for patients of reproductive age facing oncologic treatment. This study aimed to investigate how fatherhood was achieved in a patient cohort of adolescents and young adults (AYAs) banking semen at time of cancer diagnosis and to determine the effectiveness of cryopreservation aimed at fertility preservation in the cohort.
Materials And Methods: Observational cohort study examining AYAs with a cancer diagnosis who underwent semen banking for fertility preservation at Karolinska University Hospital 1988-2020, as part of the Stockholm regional fertility preservation program.
"I am a guest man in a world of women": The lived experiences of gay fathers utilizing human milk donations for their babies.
Soc Sci Med
January 2025
The Louis and Gabi Weisfeld School of Social Work, Bar Ilan University, Israel. Electronic address:
This study explores the lived experiences of gay fathers in Israel who receive human milk donations for their infants born abroad through surrogacy. Unlike regulated milk banks, peer-to-peer milk sharing is an informal, unregulated practice often facilitated through online platforms, where health risks and personal trust become central concerns. Using a phenomenological multiple case study approach, semi-structured interviews were conducted with eight families, yielding four main themes: (1) Interruption versus continuity, (2) Lack and compensation, (3) Inclusion and exclusion, and (4) Concrete and symbolic attributes of human milk.
View Article and Find Full Text PDFFatherhood experiences: A qualitative approach of cisgender and transgender fathers in assisted reproductive technologies (ART) situation with sperm donation.
Heliyon
November 2024
Service de Psychiatrie de l'Enfant et de l'Adolescent, Institut IDEAL, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France.
Assisted reproductive technologies have offered new ways and pathways to conceive a child. However, very few is known about insights into the complexities and challenges faced by trans fathers in contemporary parenthood journeys. This qualitative study explores the experiences of transgender and cisgender fathers who conceived children through donor sperm insemination (DSI) and natural conception (NC).
View Article and Find Full Text PDFConsecutive disruption of intrahepatic bile ducts after ABO-incompatible living-donor re-liver transplantation: A case report.
Int J Surg Case Rep
December 2024
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. Electronic address:
Introduction: Hyperacute rejection leading to hepatic necrosis or intrahepatic bile duct stricture in ABO incompatible living-donor liver transplant (ABO-i LDLT) has been reported many times. With the advent of rituximab, the incidence of these complications has decreased significantly. However, consecutive biliary disruption after ABO-i LDLT has rarely been reported.
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