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Computational biology assisted exploration of phytochemicals derived natural inhibitors to block BZLF1 gene activation of Epstein-Bar virus in host.
Sci Rep
December 2024
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
The Epstein-Barr virus (EBV) is widespread and has been related to a variety of malignancies as well as infectious mononucleosis. Despite the lack of a vaccination, antiviral medications offer some therapy alternatives. The EBV BZLF1 gene significantly impacts viral replication and infection severity.
View Article and Find Full Text PDFPerceived training needs by tutors of family and community medicine and nursing of specialized health training: a qualitative descriptive study.
Front Med (Lausanne)
December 2024
Unidad Docente de Atención Familiar y Comunitaria Costa Ponent, Institut Català de la Salut, Barcelona, Spain.
Introduction: Specialized Health Training is a postgraduate training pathway in which physicians and nurses can choose to continue their learning and obtain the qualification of specialist professional in a specific field. The training is eminently practical with different clinical tracks in which nurses and physicians are tutored by clinician tutors. Our research aims to describe the experiences and perceptions of clinician tutors related to their own teaching performance and training needs.
View Article and Find Full Text PDFSuture techniques in the surgical management of flexor tendon, Achilles tendon and cruciate ligament injuries: a systematic review.
BMC Musculoskelet Disord
December 2024
Department of Orthopedics, The First Hospital of Qinhuangdao, Qinhuangdao, China.
Objective: To provide clinicians with reliable recommendations for the selection of appropriate suturing techniques for surgical management of common musculoskeletal soft tissue injuries.
Methods: A systematic search of PubMed, Springer, Web Science, Vip Database, China National Knowledge, and Wanfang Data for in vitro biomechanical studies on suture techniques in the surgical treatment of musculoskeletal soft tissue injuries covering relevant studies from April 2009 to April 2024 was performed. A generalized classification was made based on the characteristics of the techniques, and recommendations for the selection of suture techniques were made according to the GRADE concept.
Construction and validation of coronary heart disease risk prediction model for general hospitals in Tacheng Prefecture, Xinjiang, China.
Front Cardiovasc Med
December 2024
Department of Cardiovascular Medicine, Tacheng People's Hospital, Tacheng, China.
Objective: To analyze the risk factors for coronary heart disease (CHD) in patients hospitalized in general hospitals in the Tacheng Prefecture, Xinjiang, and to construct and verify the nomogram prediction model for the risk of CHD.
Methods: From June 2022 to June 2023, 489 CHD patients (CHD group) and 520 non-CHD individuals (control group) in Tacheng, Xinjiang, were retrospectively selected. Using a 7:3 ratio, patients were divided into a training group (706 cases) and a validation group (303 cases).
The use of hydrogel microspheres as cell and drug delivery carriers for bone, cartilage, and soft tissue regeneration.
Biomater Transl
September 2024
Biomedical Engineering Program, Westlake University, Hangzhou, Zhejiang Province, China.
Bone, cartilage, and soft tissue regeneration is a complex process involving many cellular activities across various cell types. Autografts remain the "gold standard" for the regeneration of these tissues. However, the use of autografts is associated with many disadvantages, including donor scarcity, the requirement of multiple surgeries, and the risk of infection.
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