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Cost-effectiveness of nivolumab combined with chemotherapy as a first-line therapy for patients with unresectable or metastatic urothelial carcinoma.
Ther Adv Med Oncol
December 2024
Department of Pharmacy, Fujian Medical University Union Hospital, Xinquan Road 29, Fuzhou, Fujian 350001, China.
Background: Urothelial carcinoma is a significant health concern in the United States (US), with high mortality and economic burdens. The CheckMate-901 trial showed promising survival benefits for nivolumab combined with gemcitabine and cisplatin followed by nivolumab maintenance therapy (nivolumab-combination) as first-line treatment of unresectable or metastatic urothelial carcinoma (UC), but its cost-effectiveness is unclear.
Objectives: This study aimed to evaluate the cost-effectiveness of the nivolumab-combination versus standard chemotherapy (gemcitabine-cisplatin) for advanced UC from the perspective of healthcare payers in the US.
"It's not a pain you can fix": A qualitative exploration of working with vulnerably positioned current and bereaved carers across sectors of health and social care.
Death Stud
December 2024
IMPACCT - Improving Palliative, Aged and Chronic Care through Clinical Research and Translation, Faculty of Health, University of Technology Sydney, Sydney, Australia.
Caring for someone with a life-limiting illness is associated with complex psychosocial sequelae; amplified for carers experiencing structural vulnerability. Workers across sectors of health and social care provide support for vulnerably positioned carers, yet exploration of the impacts of this work has predominantly focused on health professionals directly engaged with death and dying. This qualitative study explored ways in which palliative care and welfare workers experience work with current and bereaved carers of people with life-limiting illness, in a region associated with socioeconomic disadvantage.
View Article and Find Full Text PDFCould the Inflation Reduction Act Maximum Fair Price Hurt Patients?
J Health Econ Outcomes Res
November 2024
Global Healthy Living Foundation, Upper Nyack, New York, USA.
The Inflation Reduction Act's Medicare Drug Price Negotiation Program allows the federal government to negotiate caps for select medications. These price caps may reduce revenue for the pharmacy benefit managers (PBMs) that negotiate the actual price paid for medicines in the U.S.
View Article and Find Full Text PDFNegotiating care and control: Pet euthanasia as phronetic action.
J Aging Stud
December 2024
University of Turku, School of History, Culture and Arts Studies, 20014, Finland. Electronic address:
The lives and deaths of animals living with humans have become increasingly medicalised, and the life of a pet usually ends with euthanasia conducted by a veterinarian. In this paper, I explore how pet euthanasia is understood as a good death in interactions between vets and pet guardians in veterinary practice, provided as an act of care for old and seriously ill or injured animals. Drawing from interviews with vets in Finland, I discuss the ways in which care and control are negotiated in the decisions and practices concerning pet euthanasia, and their implications on understandings of old age and death in animals.
View Article and Find Full Text PDFThe 2024 report of the Lancet Countdown on health and climate change: facing record-breaking threats from delayed action.
Lancet
November 2024
Institute for Global Health, University College London, London, UK.
Article Synopsis
- The world is nearing the critical threshold of 1.5°C warming, with 2023 recording an average temperature rise of 1.45°C since pre-industrial times, leading to severe climate-related impacts.
- The Countdown collaboration, formed to assess the health impacts of climate change post-Paris Agreement, involves over 300 experts analyzing data and trends annually.
- The 2024 report highlights troubling increases in climate-related health risks, such as a staggering 167% rise in heat-related deaths among seniors, indicating worsening conditions affecting wellbeing globally.
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