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Machine learning for antimicrobial peptide identification and design.
Nat Rev Bioeng
May 2024
Machine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Artificial intelligence (AI) and machine learning (ML) models are being deployed in many domains of society and have recently reached the field of drug discovery. Given the increasing prevalence of antimicrobial resistance, as well as the challenges intrinsic to antibiotic development, there is an urgent need to accelerate the design of new antimicrobial therapies. Antimicrobial peptides (AMPs) are therapeutic agents for treating bacterial infections, but their translation into the clinic has been slow owing to toxicity, poor stability, limited cellular penetration and high cost, among other issues.
View Article and Find Full Text PDFIMPACT OF PLANNED RESEARCH GAP YEAR ON UROLOGY RESIDENCY MATCH SUCCESS.
Urology
January 2025
Department of Urology, Loyola University Medical Center, Maywood, IL.
Objective: To assess the impact of a planned research gap year (RGY) on match outcomes and research productivity among urology residency applicants in the context of the highly competitive urology specialty and the new pass/fail format for the USMLE Step 1 exam.
Methods: We conducted an IRB-approved analysis of applicants to our program during the 2022-2023 and 2023-2024 application cycles. Data on demographics, medical school rank, having a home urology program, USMLE Step 1 scores, and ERAS research entries were collected.
Recent and future trends in osteopathic orthopedic surgery residency match rates following the transition to a single accreditation system.
J Osteopath Med
January 2025
Department of Orthopedic Surgery, Yale Medicine, Orthopedics and Rehabilitation, New Haven, CT, USA.
Context: Medical education in the United States has undergone significant changes, specifically within the osteopathic community. In 2020, a merger occurred between the American Osteopathic Association (AOA) and the Accreditation Council for Graduate Medical Education (ACGME), forming a single accreditation system (SAS) for graduate medical education and residency placement, with the purpose to create consistency within graduate medical education and to provide equal opportunities for applicants pursuing all specialties in medicine. However, osteopathic medical students, especially students applying to competitive residencies including orthopedic surgery, have faced challenges, raising concerns about future implications within this field.
View Article and Find Full Text PDF"The impact of the Little Orange Book on how parents/carers manage symptoms of illness in children: A mixed methods study".
PLoS One
January 2025
Department of Social Work, Education and Community Wellbeing, Northumbria University, Newcastle Upon Tyne, United Kingdom.
Background: Previous literature has highlighted the complexity of supporting an acutely unwell child and the unnecessary use of services by parents/carers. The Little Orange Book (LOB) was developed as an information resource for parents/carers of young children to assist in managing symptoms of childhood illness and to encourage the appropriate use of healthcare services.
Objectives: This study aimed to understand parent/carer views and experiences using the Little Orange Book.
Correlation Between Gender of Department Chairs and Paid Parental Leave Benefits in Academic Dermatology Residency Programs.
Cureus
December 2024
Radiology, Vancouver General Hospital, Vancouver, CAN.
Background: Although the number of women entering dermatology residency programs is increasing, they still encounter numerous challenges and disparities, including limited career opportunities and difficulties in balancing family planning with their professional lives. Parental leave policies have been recognized for their positive impact on maternal, fetal, and familial well-being, career satisfaction, and gender equality. However, negative perceptions and a lack of awareness surrounding these policies may discourage female residents from taking parental leave during training.
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