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Analysis of preferences and responses to recall in adolescent and young adult head and neck cancer survivors treated with radiotherapy.
Support Care Cancer
March 2025
BC Cancer - Vancouver Centre, 600 W 10th Ave, Vancouver, BC, V5K 4E6, Canada.
Purpose: Adolescents and young adult survivors of head and neck cancers are at risk of long-term complications stemming from their diagnosis and treatment. A cross-sectional study was performed on recalled survivors with the objective of reviewing their response to recall and preferences for ongoing care, to determine health service use before recall, and to describe knowledge and information seeking.
Methods: Survivors of head and neck cancer diagnosed between the ages 15-39 during the period 1970-2010 and treated with radiotherapy were invited to the survey.
Integration of intratumoral and peritumoral CT radiomic features with machine learning algorithms for predicting induction therapy response in locally advanced non-small cell lung cancer.
BMC Cancer
March 2025
Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, No. 288 Tianwen Road, Nan'an District, Chongqing, 400010, China.
Objectives: To extract intratumoral, peritumoral, and integrated intratumoral-peritumoral CT radiomic features, develop multi-source radiomic models using various machine learning algorithms to identify the optimal model, and integrate clinical factors to establish a nomogram for predicting the therapeutic response to induction therapy(IT) in locally advanced non-small cell lung cancer.
Methods: This study included 209 patients with locally advanced non-small cell lung cancer (LA-NSCLC) who received IT as the training cohort, and an external validation cohort comprising 50 patients from another center. Radiomic features were extracted from intratumoral, peritumoral, and integrated intratumoral-peritumoral regions by manually delineating the gross tumor volume (GTV) and an additional 3 mm surrounding area.
Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery.
BMJ Open
March 2025
Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina, USA
Introduction: Postoperative delirium occurs in up to 40% of older surgical patients and has been associated with prolonged hospital stays, long-term cognitive impairment and increased 1-year postoperative mortality. Postoperative sleep disturbances may increase the risk of delirium, but studies investigating pharmacotherapies to improve postoperative sleep to prevent delirium remain limited. Suvorexant is a selective antagonist of orexin 1 and 2 receptors and is approved for insomnia pharmacotherapy by the Food and Drug Administration.
View Article and Find Full Text PDFPurpose: To elicit the signs and/or symptoms, and impacts on daily living experienced by patients with alpha-1 antitrypsin deficiency-associated liver disease (AATD-LD).
Methods: A preliminary "concept list" of signs and/or symptoms, and impacts was developed from a targeted literature review, patient blog posts, and clinician interviews. Subsequently, one-to-one concept elicitation interviews involving English-speaking, US adults with AATD-LD and a protease inhibitor (Pi) ZZ or MZ genotype were conducted by trained interviewers following a central Institutional Review Board-approved discussion guide.
Surgical versus percutaneous closure of post-infarction ventricular septal rupture; review of literature and single-center experience.
BMC Cardiovasc Disord
March 2025
Department of Cardiology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Kasr Al-Ainy Street, Cairo, Egypt.
Background: Post-infarction ventricular septal rupture (PIVSR) is a rare mechanical complication, characterized by a dismal prognosis. Despite the widespread timely reperfusion and recent advances in management, short-term mortality of PIVSR remains high. The complexity of the hemodynamic profile, confusing evidence for the optimal timing for intervention, and lack of head-to-head trials, all make the management of such a condition very challenging.
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