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Comparative Analysis of Tenecteplase versus Alteplase in Acute Ischemic Stroke: A Multicentric Observational Study from Eastern India.
Ann Indian Acad Neurol
May 2024
Department of Neurology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India.
Background: Tenecteplase is used as an alternative to alteplase and is considered noninferior for thrombolysis in acute ischemic stroke.
Objectives: To compare the effectiveness and adverse effects of tenecteplase and alteplase in the real-world management of acute ischemic stroke.
Materials And Methods: In this retrospective observational study, we collected data from acute ischemic stroke patients admitted in six hospitals in West Bengal, India, and were thrombolysed with tenecteplase or alteplase between July 2021 and June 2022.
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : Mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes.
Can J Psychiatry
September 2024
Department of Psychiatry, Queen's University, Kingston, ON, Canada.
Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT) last published clinical guidelines for the management of major depressive disorder (MDD) in 2016. Owing to advances in the field, an update was needed to incorporate new evidence and provide new and revised recommendations for the assessment and management of MDD in adults.
Methods: CANMAT convened a guidelines editorial group comprised of academic clinicians and patient partners.
Predicting recurrence of major depressive episodes using the Depression Implicit Association Test: A Canadian biomarker integration network in depression (CAN-BIND) report.
Psychiatry Res
December 2023
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Identifying clinically relevant predictors of depressive recurrence following treatment for Major Depressive Disorder (MDD) is critical for relapse prevention. Implicit self-depressed associations (SDAs), defined as implicit cognitive associations between elements of depression (e.g.
View Article and Find Full Text PDFMolecular etiology of defective nuclear and mitochondrial ribosome biogenesis: Clinical phenotypes and therapy.
Biochimie
April 2023
Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India. Electronic address:
Ribosomopathies are rare congenital disorders associated with defective ribosome biogenesis due to pathogenic variations in genes that encode proteins related to ribosome function and biogenesis. Defects in ribosome biogenesis result in a nucleolar stress response involving the TP53 tumor suppressor protein and impaired protein synthesis leading to a deregulated translational output. Despite the accepted notion that ribosomes are omnipresent and essential for all cells, most ribosomopathies show tissue-specific phenotypes affecting blood cells, hair, spleen, or skin.
View Article and Find Full Text PDFHigh-Entropy Borides under Extreme Environment of Pressures and Temperatures.
Materials (Basel)
April 2022
High Pressure Collaborative Access Team (HPCAT), X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA.
Article Synopsis
- High-entropy borides (HEB) with multiple metal elements show promise for materials that can withstand extreme conditions due to their crystalline stability, strength, and thermal resistance.
- The study explores HEBs like (Hf, Mo, Nb, Ta, Ti)B and (Hf, Mo, Nb, Ta, Zr)B through theoretical modeling and extensive experiments at high pressures and temperatures, yielding significant findings.
- Results reveal a bulk modulus of about 276 GPa and compressive yield strength of 28 GPa at 65 GPa pressure, indicating their suitability for use in demanding applications like nuclear and aerospace technology.
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