Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Preliminary examination of orexin receptor antagonism with suvorexant in individuals with Methamphetamine use disorder: a case series study.
J Addict Dis
December 2024
Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
No FDA-approved medications for methamphetamine (MA) use disorder (MUD) are available. Suvorexant (SUVO), a dual orexin receptor antagonist that is FDA approved for insomnia treatment, reduces MA self-administration and MA-induced reinstatement responding in preclinical studies. SUVO may also reduce MA use by targeting substance use risk factors, including insomnia, stress, cue reactivity, and craving.
View Article and Find Full Text PDFHabitual pre-exercise caffeine supplementation prevents exercise-training induced attenuation of exercising systolic blood pressure and double-product.
J Appl Physiol (1985)
December 2024
Integrative Laboratory of Applied Physiology & Lifestyle Medicine, Department of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
We examined the effect of habitual pre-exercise caffeine supplementation on training-induced adaptations to exercising systolic (SBP), diastolic (DBP), pulse pressure (PP), heart rate (HR), and double product (DP). Young women (mean±SD; 24±7 y) were randomized to a caffeine (120 mg) supplement (CAF; n=17) or placebo (PLA; n=16) group, completed 6-weeks of high intensity exercise training on three non-consecutive days per week, and supplemented with CAF or PLA 30-60 minutes before exercise or else upon waking. Before (PRE) and after (POST) the intervention, SBP, DBP, and HR were measured, and PP and DP calculated, at rest and during fixed-power exercise at 50W and 75W.
View Article and Find Full Text PDFRobust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy.
EBioMedicine
December 2024
Department of Neurosurgery, Stanford University, Stanford, CA, USA.
Background: Perivascular spaces (PVS) on brain MRI are surrogates for small parenchymal blood vessels and their perivascular compartment, and may relate to brain health. However, it is unknown whether PVS can predict dementia risk and brain atrophy trajectories in participants without dementia, as longitudinal studies on PVS are scarce and current methods for PVS assessment lack robustness and inter-scanner reproducibility.
Methods: We developed a robust algorithm to automatically assess PVS count and size on clinical MRI, and investigated 1) their relationship with dementia risk and brain atrophy in participants without dementia, 2) their longitudinal evolution, and 3) their potential use as a screening tool in simulated clinical trials.
Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.
J Int Soc Sports Nutr
December 2025
İnönü University, Department of Physical Education and Sports, Faculty of Education, Malatya, Turkey.
Background: Taekwondo is a complex martial art that requires speed, balance, agility, and endurance. This study aims to examine the effects of nitrate and L-arginine supplementation on acute aerobic and anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.
Method: This study was conducted as a double-blind, randomized, crossover study with the participation of 15 experienced taekwondo athletes aged 19.
Placebo and the law of identification.
Front Psychiatry
December 2024
College of Medicine, University of Arizona, Tucson, AZ, United States.
Thousands of essays and studies have been published on placebo and nocebo. Yet, despite this plethora of information, we are not much closer to a comprehensive understanding of the fundamental mechanism producing placebo and nocebo effects than we were in 1946, when participants in the Cornell Conferences on Therapy speculated on the roles of authority, belief and expectancy. In this paper, we examine the weaknesses in current placebo and nocebo definitions and theories.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!