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Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Am J Obstet Gynecol
March 2024
Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, and Detroit, MI; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Clinical chorioamnionitis, the most common infection-related diagnosis in labor and delivery units, is an antecedent of puerperal infection and neonatal sepsis. The condition is suspected when intrapartum fever is associated with two other maternal and fetal signs of local or systemic inflammation (eg, maternal tachycardia, uterine tenderness, maternal leukocytosis, malodorous vaginal discharge or amniotic fluid, and fetal tachycardia). Clinical chorioamnionitis is a syndrome caused by intraamniotic infection, sterile intraamniotic inflammation (inflammation without bacteria), or systemic maternal inflammation induced by epidural analgesia.
View Article and Find Full Text PDFA new rapid bedside test to diagnose and monitor intraamniotic inflammation in preterm PROM using transcervically collected fluid.
Am J Obstet Gynecol
September 2020
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, South Korea. Electronic address:
Background: Microbial invasion of the amniotic cavity, a clinical condition present in approximately 50% of patients with preterm prelabor rupture of membranes, is often associated with intraamniotic inflammation, a risk factor for a short admission-to-delivery interval, early preterm delivery, and neonatal complications. We previously developed a transcervical amniotic fluid collector, the device that allows the collection of fluid noninvasively from the cervical canal when membrane rupture occurs.
Objective: This study was designed to determine whether rapid analysis of an interleukin-8 concentration in fluid obtained noninvasively by the transcervical amniotic fluid collector can be used to assess the risk of intraamniotic inflammation.
Risk factors for failed chorionic villus sampling: results of a 4-year retrospective study.
J Matern Fetal Neonatal Med
January 2022
Department of Genetics, University Hospital of Amiens, CHU Amiens-Picardie, Amiens, France.
Article Synopsis
- Chorionic villus sampling (CVS) offers quicker results for detecting genetic abnormalities compared to amniocentesis, but it has a higher rate of incomplete results, prompting this study to seek risk factors for such failures.
- The study, conducted from January 2014 to December 2018, involved 214 CVS procedures, revealing that 34% resulted in failures, with significant differences noted between successful and failed cases related to BMI, gestational age, trophoblastic location, and type of sampling approach.
- Key factors negatively impacting the success of CVS included higher BMI, the posterior position of the trophoblast, and a transcervical sampling method; these findings suggest considering amni
Procedure related risk of premature delivery and fetal growth reduction following amniocentesis, transcervical and transabdominal chorionic villus sampling: a retrospective study.
J Perinat Med
October 2019
Department of Obstetrics and Gynecology, University Hospital Münster, Münster, Germany.
Background The aim of this study was to compare transabdominal and transcervical chorionic villus sampling (CVS) as well as amniocentesis (AC) with respect to their rates of premature delivery and fetal growth restriction. Methods We retrospectively evaluated the mentioned procedures of invasive prenatal testing performed in a single center between 2001 and 2016. Seven hundred and ninety-nine cases of AC and 719 cases of CVS were included, of which 400 were performed transvaginally.
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