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A Swiss family with hemoglobin P Galveston beta117His leads to Arg, including two patients with hb P/beta thalassemia. | LitMetric

AI Article Synopsis

  • The Hb P Galveston mutation (beta117His leads to Arg) occurs in individuals with beta thalassemia but does not produce any noticeable clinical symptoms on its own.
  • The physical and chemical properties of Hb P Galveston closely resemble those of another mutation, hemoglobin Zurich (beta 63 His leads to Arg).
  • Detailed analysis was necessary to differentiate between these two hemoglobin variants due to their similarities.

Article Abstract

The mutant Hb P Galveston (beta117His leads to Arg) is observed in two heterozygotes for beta thalassemia and by itself does not cause clinical symptoms. Some of the physico-chemical properties of Hb P Galveston are identical to the onemical properties of Hb P Galveston are identical to the ones hemoglobin Zurich (beta 63 His leads to Arg) so that only a detailed analysis led to its proper identification.

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Source
http://dx.doi.org/10.1007/BF01633721DOI Listing

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