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Characterizing Antisense Oligonucleotide-Induced Histopathology Findings in Spinal Cord of Mauritius Cynomolgus Monkeys by Molecular Localization Investigation.
Toxicol Pathol
January 2025
Novartis Institute for Biomedical Research, Cambridge, Massachusetts, USA.
The safety of a 2'--methoxyethyl antisense oligonucleotide (ASO) was investigated in Mauritius cynomolgus monkeys in a 41-week Good Laboratory Practice (GLP) toxicity study after multiple intrathecal (IT) administrations. Histopathological examination revealed ectopic formation of lymphoid follicles in the spinal cord (SC) at the injection site at all doses and the presence of granular material in neurons of the SC in high-dose animals. The granular material was seen in all the segments of the SC, but mainly in the lumbar segment and persisted at the end of the 26-week recovery period, while the lymphoid follicles showed a reversibility trend.
View Article and Find Full Text PDFEvaluating the Impact of Preoperative Nutritional Status on Surgical Outcomes and Public Health Implications in General Surgery Patients.
Cureus
December 2024
General Surgery, Institute DHQ Hospital Dassu, Upper Kohistan, PAK.
Background: Malnutrition is linked to more postoperative problems, a longer recovery period, and a higher death rate; preoperative nutritional condition is a critical factor in surgical outcomes.
Objective: This study aimed to evaluate the impact of preoperative nutritional status on surgical outcomes in general surgery patients and explore its broader public health implications.
Methodology: A two-year observational research with 440 adult patients undergoing general surgery was carried out between January 2022 and December 2023.
Modelling and analysis of an epidemic model with awareness caused by deaths due to fear.
J Biol Dyn
December 2025
College of Mathematical Sciences, Harbin Engineering University, Harbin, Heilongjiang, People's Republic of China.
In this paper, we establish a compartmental model in which the transmission rate is associated with the fear of being infected by COVID-19. We provide a detailed analysis of the epidemic model and established results for the existence of a positively invariant set. The expression of the basic reproduction number is characterized.
View Article and Find Full Text PDFGlobal regional and national burden of intracerebral hemorrhage between 1990 and 2021.
Sci Rep
January 2025
Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Intracerebral hemorrhage (ICH) represents one of the most devastating forms of stroke, characterized by spontaneous bleeding into the brain parenchyma. This neurological emergency carries a substantial burden of mortality and long-term disability worldwide. A comprehensive understanding of ICH's evolving global impact from 1990 to 2021 remains essential for healthcare planning and resource allocation.
View Article and Find Full Text PDF[Quality evaluation of Brazilian Mortality Information System (SIM): a scoping review].
Cien Saude Colet
January 2025
Centro de Integração de Dados e Conhecimentos para a Saúde, Fundação Oswaldo Cruz. R. Mundo 121, Edf. Tecnocentro, Ps 315, Trobogy. 41745-715 Salvador BA Brasil.
The aim was to map evidence on the quality of records in the Mortality Information System (SIM) through a national scoping review of articles published up to April 2023 across five databases (PubMed, Embase, Scopus, LILACS, and SciELO). Studies focused on specific causes of death were excluded. Dimensions evaluated included accessibility, methodological clarity, coverage, completeness, reliability, consistency, non-duplication, timeliness, validity, and studies on ill-defined causes/garbage codes.
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