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A Pangenotypic Hepatitis E Virus Replication Inhibitor With High Potency in a Rat Infection Model.
Gastroenterology
November 2024
Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Virology, Antiviral Drug & Vaccine Research Group, KU Leuven, Leuven, Belgium. Electronic address:
Background & Aims: Hepatitis E virus (HEV) constitutes a substantial public health burden with ∼20 million human infections annually, including 3.3 million symptomatic cases. Appropriate treatment options for, in particular, immunocompromised patients with HEV infection and pregnant women are lacking, underscoring the urgent need for potent and safe antiviral drugs.
View Article and Find Full Text PDFAssessment of magnitude of medicines wastage and the contributing factors in selected public health facilities of Hadiya Zone, Central Ethiopia Regional State.
BMC Public Health
October 2024
Bobicho Health Center Adult OPD Focal (MD, MPH), Hossaena City Administration Health Office, Hossaena, Ethiopia.
Background: Medicine wastage occurs when medicines are damaged, obsolete, or expired and become unsafe for use. In Ethiopia, although there are reports that reveal the presence of wasted medicines in the country, there is limited objective evidence on the type and extent of medicine wastage as well as its contributing factors.
Objective: The study aimed to assess the medicine wastage rate and identify its contributing factors in the sampled public health facilities (HFs) in Hadiya Zone, Central Ethiopia Regional State.
Important Drugs and Its Patterns during the Late Goryeo Dynasty -Obtain and distribution of Bupleuri Radix and Ginger.
Uisahak
August 2024
Research Professor, Department of Medical History, Yonsei University College of Medicine.
This article deals with drugs obtain and distribution during the Goryeo Dynasty. In particular, I analyzed the case of 'Bupleuri Radix', which corresponds to 'dot-ui minali' as Idu, an archaic Korean notation, and Ginger, which was intentionally introduced and cultivated in Goryeo. Drugs of the Goryeo Dynasty can be classified into 5 types.
View Article and Find Full Text PDFPrevalence, reasons and factors associated with intentional nonadherence to prescribed medications: a population-based study.
Rev Bras Epidemiol
October 2024
Universidade Federal do Rio Grande do Sul, School of Medicine, Graduate Program in Epidemiology - Porto Alegre (RS), Brazil.
Objective: To evaluate the frequency, reasons and factors associated with intentional nonadherence to drug therapy.
Methods: A population-based cross-sectional study was conducted with data from the National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM). The questionnaire consisted of sociodemographic questions, presence of chronic diseases, medication use, self-rated health, and medication use behaviors.
Perception and barriers to access Pre-exposure Prophylaxis for HIV/AIDS (PrEP) among the MSM (men who have sex with men) Brazilian Amazon: A qualitative study.
PLoS One
September 2024
Universidade do Estado do Amazonas, Manaus, Brazil.
Pre-exposure prophylaxis (PrEP) is an effective HIV prevention strategy that consists in the use of antiretroviral drugs by seronegative people at risk of HIV. Negative perceptions, inadequate understanding, and access barriers have been associated with decreased medication adherence. Manaus is the largest city in the Brazilian Amazon, where the incidence of HIV/AIDS is high, and the rates of adherence to the antiretroviral treatment for HIV and PrEP are low.
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