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Conserved ancillary residues situated proximally to the VIM-2 active-site affect its metallo β-lactamase activity.
FEMS Microbiol Lett
January 2025
Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur-721302, West Bengal, India.
Verona-integron-metallo-β-lactamase (VIM-2) is one of the most widespread class B β-lactamase responsible for β-lactam resistance. Although active-site residues help in metal binding, the residues nearing the active-site possess functional importance. Here, to decipher the role of such residues in the activity and stability of VIM-2, the residues E146, D182, N210, S207, and D213 were selected through in-silico analyses and substituted with alanine using site-directed mutagenesis.
View Article and Find Full Text PDFGlobal surgery and climate change: how global surgery can prioritise both the health of the planet and its people.
BMC Surg
January 2025
Global Surgery Division, Department of Surgery, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Climate change is an emerging global health crisis, disproportionately affecting low- and middle-income countries (LMICs) where health outcomes are increasingly compromised by environmental stressors such as pollution, natural disasters, and human migration. With a focus on promoting health equity, Global Surgery advocates for expanding access to surgical care and enhancing health outcomes, particularly in resource-limited and disaster-affected areas like LMICs. The healthcare industry-and more specifically, surgical care-significantly contributes to the global carbon footprint, primarily through resource-intensive settings, i.
View Article and Find Full Text PDFThe Multidrug and toxin compound extrusion gene GhTT12 promotes the accumulation of both proanthocyanidins and anthocyanins in Gossypium hirsutum.
Plant Physiol Biochem
January 2025
Plant Genomics and Molecular Improvement of Colored Fiber Laboratory, Zhejiang Sci-Tech University, Hangzhou, 310018, China. Electronic address:
The pigments present in the fibers of naturally colored cotton provide excellent antibacterial and environmentally friendly properties, making these colored fibers increasingly favored by the textile industry and consumers. Proanthocyanidins (PAs), the critical pigments responsible for the color of brown cotton fiber, are produced on the endoplasmic reticulum and subsequently transported to the vacuole for polymerization and/or storage. Previous studies have identified GhTT12 as a potential transmembrane transporter of PAs in Gossypium hirsutum, with GhTT12 being a homolog of Arabidopsis Transparent Testa 12 (TT12).
View Article and Find Full Text PDFDifferentially expressed messenger RNA isoforms in beef cattle skeletal muscle with different fatty acid profiles.
Meat Sci
January 2025
São Paulo State University (UNESP), School of Agricultural and Veterinarian Sciences, Department of Animal Science, Via de Acesso Prof. Paulo Donato Castelane, Jaboticabal, SP 14884-900, Brazil; National Council for Science and Technological Development, Brasilia, DF 71605-001, Brazil. Electronic address:
This study aimed to identify mRNA isoforms that were expressed differently in the muscle tissue of Nellore cattle based on their intramuscular fatty acid profile. Forty-eight young bulls were used to quantify beef fatty acids (FA) and perform RNA sequencing analysis. The young bulls were divided into three different groups based on quantifying FA using k-means analysis.
View Article and Find Full Text PDFFoliar application of nitrates limits lead uptake by Cucumis sativus L. plants.
J Trace Elem Med Biol
January 2025
Department of Molecular Plant Physiology, Institute of Environmental Biology, Faculty of Biology, University of Warsaw, Ilji Miecznikowa 1, Warszawa 02-096, Poland.
Lead is a toxic heavy metal, which accumulates in the soil and is readily absorbed by plant roots. The uptake of toxic elements by crops is a serious threat to human health. For this reason, it is important to prevent the incorporation of heavy metals into the food chain.
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