AI Article Synopsis
- The study investigates the impact of three mouthrinse products (chlorhexidine, cetylpyridinium chloride, and triclosan) on the adhesion of Candida albicans to human epithelial cells, which is crucial for infection.
- Chlorhexidine and cetylpyridinium chloride were found to significantly reduce Candida adhesion, while triclosan showed no significant effect.
- The results suggest that mouthrinses with chlorhexidine or cetylpyridinium chloride may help manage oral Candida infections, indicating a need for further clinical trials.
Article Abstract
Adhesion to epithelial cells is a critical step in successful oral colonization and infection by Candida albicans. Therefore, three mouthrinse products, containing chlorhexidine 0.2% (CHX), cetylpyridinium chloride 0.05% (CPC) or triclosan 0.045% (TRN), were compared for their effects on the in vitro adhesion of C. albicans to human buccal epithelial cells (BEC). Candidal adhesion appeared to be significantly reduced by oral rinsing with the CHX-containing mouthrinse (P<0.0001). In vivo exposure of BEC to the CPC mouthrinse also inhibited adhesion of C. albicans (P<0.0001). Both CHX and CPC products suppressed adhesion to the same extent (P>0.01). On the other hand, the TRN mouthrinse did not significantly affect epithelial adhesion of C. albicans (P>0.01). These findings suggest that mouthrinses containing CHX or CPC could be of value in the control of candidal colonization and infection. Clinical trials are warranted on the effectiveness of these products in reducing oral Candida carriage.
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| http://dx.doi.org/10.1007/s007840100121 | DOI Listing |
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