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Narcolepsy in early childhood: a case report and a Mini review.
Front Pediatr
January 2025
Department of Medical Psychology, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Narcolepsy is a sleep-wake disorder with an onset commonly seen in individuals aged 10-30 years. Due to various reasons, the diagnosis of narcolepsy often experiences a delay of at least ten years. Diagnosing narcolepsy in children is particularly challenging due to atypical symptoms, leading to frequent misdiagnosis or missed diagnoses.
View Article and Find Full Text PDFAlterations of gray matter volume and functional connectivity in patients with cognitive impairment induced by occupational aluminum exposure: a case-control study.
Front Neurol
January 2025
School of Public Health, Shanxi Medical University, Taiyuan, China.
Background: Cognitive impairment (CI) is a condition in which an individual experiences noticeable impairment in thinking abilities. Long-term exposure to aluminum (Al) can cause CI. This study aimed to determine the relationship between CI and MRI-related changes in postroom workers exposed to Al.
View Article and Find Full Text PDFA case report of hypospadias combined with polyorchidism.
Urol Case Rep
January 2025
Department of Urology, General Hospital of Central Theater Command of Chinese People's Liberation Army, China.
Hypospadias is a common congenital malformation of the reproductive system; however, to date, no cases of hypospadias complicated by polyorchidism have been reported in the literature. This article reports a case of a 1-year-old boy presenting with hypospadias, who was also diagnosed with polyorchidism combined with cryptorchidism. Preoperative Doppler ultrasound revealed two testes on the right side, and an atrophic testis on the left.
View Article and Find Full Text PDFNTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas.
Pathol Oncol Res
January 2025
Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
The () gene family is of rising importance as their fusions are oncogenic, and specific target drugs are available to inhibit the chimera proteins. Pan-TRK antibody, which shows the overexpression of the genes, is a useful tool to detect tumors with or without gene alterations, due to high negative predictive value. Though it is well known that pan-TRK immunopositivity is usually not connected to fusion, the role of other possible genetic alterations is under-researched.
View Article and Find Full Text PDFSynthesis and Chiroptical Activity of π-Expanded Electron-rich Heterohelicenes Based on the 1,4-Dihydropyrrolo[3,2-b]pyrrole core.
Chemistry
January 2025
Institute of Organic Chemistry PAS: Instytut Chemii Organicznej Polskiej Akademii Nauk, Institute of Organic Chemistry, Kasprzaka 44/52, 01-224, Warsaw, POLAND.
Herein, we report the synthesis and chiroptical characteristics of the first (double) helicenes possesing the 1,4-dihydropyrrolo[3,2-b]pyrrole (DHPP) moiety as their central core. We have developed a three-step synthesis with 6π-electrocyclization accompanied with HBr elimination as its key step. We found that, whereas for smaller periphereal arms double 6π-electrocyclization occurs smoothly forming a double helicene, in the case of longer policyclic aromatic hydrocarbons the reaction becomes less efficient and mono-helicenes are the only products.
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