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Injectable Gelatin-Palmitoyl-GDPH Hydrogels as Bioinks for Future Cutaneous Regeneration: Physicochemical Characterization and Cytotoxicity Assessment.
Polymers (Basel)
December 2024
Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Tissue engineering and regenerative medicine have made significant breakthroughs in creating complex three-dimensional (3D) constructs that mimic human tissues. This progress is largely driven by the development of hydrogels, which enable the precise arrangement of biomaterials and cells to form structures resembling native tissues. Gelatin-based bioinks are widely used in wound healing due to their excellent biocompatibility, biodegradability, non-toxicity, and ability to accelerate extracellular matrix formation.
View Article and Find Full Text PDFOptimising 3D printed medications for rare diseases: In-line mass uniformity testing in direct powder extrusion 3D printing.
Int J Pharm
January 2025
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain; Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom; FABRX Ltd., Henwood House, Henwood, Ashford, Kent TN24 8DH, United Kingdom; FABRX Artificial Intelligence, Carretera de Escairón, 14, Currelos, O Saviñao CP 27543, Spain. Electronic address:
Article Synopsis
- Biotinidase deficiency is a rare genetic disorder affecting biotin metabolism, causing various symptoms that can be treated with biotin supplements.
- The study explores using 3D printing technology to create personalized biotin dosage forms, emphasizing the importance of quality control (QC) for precise dosing in medical applications.
- Integrating a precision balance into a 3D printer allowed real-time monitoring of printlet weights, ensuring that while larger tablets met QC standards, some smaller ones did not; in vitro studies demonstrated varying release rates for immediate- and extended-release formulations.
Perindopril erbumine-entrapped ultradeformable liposomes alleviate sarcopenia via effective skin delivery in muscle atrophy mouse model.
Int J Pharm
December 2024
College of Pharmacy, Institute of Pharmaceutical Sciences and Technology, Hanyang University ERICA, Ansan 15588, Republic of Korea. Electronic address:
Sarcopenia is a pertinent challenge in the super-aged societies causing reduced functional performance, poor quality of life and increased morbidity. In this study, the potential of perindopril erbumine-loaded ultradeformable liposomes (PE-UDLs) against sarcopenia was investigated. PE-UDLs were prepared by thin-film hydration and extrusion method using egg yolk L-α-phosphatidylcholine (EPC) as a lipid bilayer former and Tween 80 or sodium deoxycholate as an edge activator.
View Article and Find Full Text PDFAn intracerebral microdialysis study to determine the neuropharmacokinetics of eribulin in patients with metastatic or primary brain tumors.
Cancer Chemother Pharmacol
December 2024
City of Hope Comprehensive Cancer Center, Department of Medical Oncology and Therapeutics Research, Duarte, CA, USA.
Article Synopsis
- Eribulin is a microtubule dynamics inhibitor that shows potential for managing brain tumors, especially breast cancer brain metastases, due to its lower protein binding and resistance to P-glycoprotein extrusion.
- A clinical study involved administering eribulin to cancer patients post-tumor removal, with samples analyzed to measure its concentrations in the brain and plasma.
- Results indicated higher concentrations of eribulin in areas where the blood-brain barrier was disrupted, but overall levels in the brain were not enough to confirm consistent clinical effectiveness against brain tumors.
Tethered cord prevalence among patients with prenatal or postnatal myelomeningocele repair.
Childs Nerv Syst
November 2024
Department of Neurological Surgery, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY, 10467, USA.
Article Synopsis
- - The study investigates outcomes of prenatal versus postnatal surgical repair of myelomeningocele (MMC), a severe form of spina bifida, focusing on factors like spinal cord tethering and other complications.
- - A total of 18 patients were reviewed from 2002 to 2020, with equal groups for prenatal and postnatal repair, and demographic data collected included age, sex, and medical history.
- - Results showed that patients who had prenatal closure experienced fewer detethering procedures and lower rates of requiring a ventriculoperitoneal shunt compared to those with postnatal repair, highlighting potential benefits of prenatal surgery.
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