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The Pathophysiology and Vascular Complications of Diabetes in Chronic Kidney Disease: A Comprehensive Review.
Cureus
December 2024
Neurosurgery, Federal Fluminense University, Niterói, BRA.
The coexistence of type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) represents a significant global health challenge, contributing to substantial morbidity, mortality, and economic burden. T2DM is the leading cause of CKD, and CKD exacerbates diabetes-related complications, creating a bidirectional relationship driven by oxidative stress, inflammation, and endothelial dysfunction. Diabetic kidney disease (DKD), affecting some individuals with T2DM, accelerates progression to end-stage renal disease (ESRD) and increases cardiovascular mortality.
View Article and Find Full Text PDFUltrasound-Guided Diagnosis and Percutaneous Drainage in Subacute Necrotizing Fasciitis of the Lower Extremities: A Report of Two Cases.
Cureus
December 2024
Emergency and General Internal Medicine, Rakuwakai Marutamachi Hospital, Kyoto, JPN.
Necrotizing fasciitis (NF) is a life-threatening disease that is diagnosed through an exploratory incision and typically requires surgical debridement. Reports of non-surgical cures are limited to specific cases, such as NF affecting only the head and neck regions. The two patients (a woman and a man) were both in their 70s and underwent maintenance dialysis for diabetic nephropathy.
View Article and Find Full Text PDFAssociation between different insulin resistance indices and all-cause mortality in patients with diabetic kidney disease: a prospective cohort study.
Front Endocrinol (Lausanne)
January 2025
Department of Urology, Harbin Medical University Cancer Hospital, Harbin, China.
Aim: Previous research has shown a strong association between insulin resistance (IR) and both the onset and advancement of diabetic kidney disease (DKD). This research focuses on examining the relationship between IR and all-cause mortality in individuals with DKD.
Methods: This study utilized data obtained from the National Health and Nutrition Examination Survey (NHANES), spanning the years 2001 to 2018.
Analysis of the potential biological mechanisms of geniposide on renal fibrosis by network pharmacology and experimental verification.
BMC Pharmacol Toxicol
January 2025
Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, Anhui, 230601, China.
Background: Renal fibrosis is crucial in the progression of chronic kidney disease (CKD) to end-stage renal failure. Geniposide, an iridoid glycoside, has shown therapeutic potential in acute kidney injury, diabetic nephropathy, and atherosclerosis. The aim of this study was to investigate the role of geniposide in renal fibrosis and its underlying mechanisms.
View Article and Find Full Text PDFRNA-seq reveals Lysyl oxidase as a potential biomarker of glomerular function in diabetic nephropathy in rats.
Gene
January 2025
College of Traditional Chinese Medicine, North China University of Science and Technology, 21 Bohai Road, Tangshan 063210 China. Electronic address:
Purpose: We downloaded the gene expression profiles of patients with diabetic nephropathyfrom the GEO database and combined it with differential gene analysis of rat transcriptome,our study employed animal models to examine the role of key hub genes in diabetic nephropathy and to pinpoint significant gene regulation in this disease.
Methods: An examination of differential expression was performed using the online analysis tool GEO2R and the DN-related datasets GSE30528 and GSE1009 obtained from the GEO database. A comparison of gene expression between the normal and diabetic nephropathy groups was conducted using the RNA-seq technique.
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