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A realist evaluation to explain and understand the role of paramedics in primary care.
BMC Med
January 2025
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Background: In response to the unsustainable workload and workforce crises in primary care, paramedics (with their generalist clinical background acquired from ambulance service experience) are increasingly employed in primary care. However, the specific contribution paramedics can offer to the primary care workforce has not been distinctly outlined. We used realist approaches to understand the ways in which paramedics impact (or not) the primary care workforce.
View Article and Find Full Text PDFAn Exploration of Alkaline Degumming in the Printing and Dyeing Process of Silk Georgette.
Polymers (Basel)
October 2024
Pan Tianshou College of Architecture, Art and Design, Ningbo University, Ningbo 315211, China.
Article Synopsis
- The study explores two degumming methods in alkaline printing on silk georgette, comparing alkaline boiling and steaming based on ancient Tang Dynasty techniques.* -
- Alkaline boiling is quicker and more effective, achieving a 27% degumming rate at 80 °C in 30 minutes, while steaming is slower, reaching under 20% before boiling.* -
- The research highlights how both methods can influence dyeing effects and pattern clarity, with alkaline steaming offering better integration with modern printing techniques for enhanced artistic expression.*
Development of a New Screening Tool for Pediatric Septic Shock.
Ann Emerg Med
December 2024
Division of Emergency Medicine, Boston Children's Hospital, Boston MA; Departments of Pediatrics and Emergency Medicine, Harvard Medical School, Boston, MA.
Study Objective: Existing screening tools for sepsis in children are limited by suboptimal sensitivity. Our objective was to develop a new, more sensitive screening tool for pediatric septic shock by enhancing 2 aspects of the 4-point Liverpool quick Sequential Organ Failure Assessment (LqSOFA) tool.
Methods: We performed a secondary analysis of a cohort of children (1 month to 18 years) who presented to a pediatric emergency department (ED) with suspected infection over a 10-year period.
Targeting Fn14 as a therapeutic target for cachexia reprograms the glycolytic pathway in tumour and brain in mice.
Eur J Nucl Med Mol Imaging
November 2024
Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, 145 Studley Road, Melbourne, Heidelberg, VIC, 3084, Australia.
Purpose: Cachexia is a complex syndrome characterized by unintentional weight loss, progressive muscle wasting and loss of appetite. Anti-Fn14 antibody (mAb 002) targets the TWEAK receptor (Fn14) in murine models of cancer cachexia and can extend the lifespan of mice by restoring the body weight of mice. Here, we investigated glucose metabolic changes in murine models of cachexia via [F]FDG PET imaging, to explore whether Fn14 plays a role in the metabolic changes that occur during cancer cachexia.
View Article and Find Full Text PDFTargeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with Zr-labelled CI-8993.
Eur J Nucl Med Mol Imaging
November 2024
Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Level 5 ONJ Centre, 145 Studley Road, Heidelberg, VIC, 3084, Australia.
Background: CI-8993 is a fully human IgG1κ monoclonal antibody (mAb) that binds specifically to immune checkpoint molecule VISTA (V-domain Ig suppressor of T-cell activation). Phase I safety has been established in patients with advanced cancer (NCT02671955). To determine the pharmacokinetics and biodistribution of CI-8993 in patients, we aimed to develop Zr-labelled CI-8993 and validate PET imaging and quantitation in preclinical models prior to a planned human bioimaging trial.
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