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Predicting land use and land cover changes for sustainable land management using CA-Markov modelling and GIS techniques.
Sci Rep
January 2025
Department of Wildlife Fisheries and Aquaculture, College of Forest Resources, Mississippi State University, Mississippi State, MS, 39762-9690, USA.
This study addresses the significant issue of rapid land use and land cover (LULC) changes in Lahore District, which is critical for supporting ecological management and sustainable land-use planning. Understanding these changes is crucial for mitigating adverse environmental impacts and promoting sustainable development. The main goal is to evaluate historical LULC changes from 1994 to 2024 and forecast future trends for 2034 and 2044 utilizing the CA-Markov hybrid model combined with GIS methodologies.
View Article and Find Full Text PDFEncorafenib, cetuximab and chemotherapy in BRAF-mutant colorectal cancer: a randomized phase 3 trial.
Nat Med
January 2025
Vall d'Hebron Hospital Campus and Vall d'Hebron Institute of Oncology (VHIO), University of Vic - Central University of Catalonia, Barcelona, Spain.
Encorafenib + cetuximab (EC) is approved for previously treated BRAF V600E-mutant metastatic colorectal cancer (mCRC) based on the BEACON phase 3 study. Historically, first-line treatment of BRAF V600E-mutant mCRC with chemotherapy regimens has had limited efficacy. The phase 3 BREAKWATER study investigated EC+mFOLFOX6 versus standard of care (SOC) in patients with previously untreated BRAF V600E mCRC.
View Article and Find Full Text PDFA historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli.
NPJ Antimicrob Resist
January 2025
College of Biological Sciences, Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Rd E, Guelph, ON, Canada.
Since its discovery nearly 60 years ago, TolC has been associated with various cellular functions in Escherichia coli, including the efflux of environmental stressors and virulence factors. It also acts as a receptor for specific bacteriophages and the colicin E1 toxin. This review highlights key discoveries over the past six decades and emphasizes the remaining gaps in understanding how TolC contributes to physiological functions in E.
View Article and Find Full Text PDFFluid flow impacts endothelial-monocyte interactions in a model of vascular inflammatory fibrosis.
Sci Rep
January 2025
Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.
The aberrant vascular response associated with tendon injury results in circulating immune cell infiltration and a chronic inflammatory feedback loop leading to poor healing outcomes. Studying this dysregulated tendon repair response in human pathophysiology has been historically challenging due to the reliance on animal models. To address this, our group developed the human tendon-on-a-chip (hToC) to model cellular interactions in the injured tendon microenvironment; however, this model lacked the key element of physiological flow in the vascular compartment.
View Article and Find Full Text PDF[The pathology of pediatric in China over the past ten years: retrospect and prospect].
Zhonghua Bing Li Xue Za Zhi
February 2025
Department of Pathology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
In the past decade, governments, including the national, provincial, municipal, and others, have increased their investment in children's health. Pathologists, especially pediatric pathologists, have greatly promoted the development and progress of pediatric pathology in China with the guidance of molecular pathological technology. This article reviews the cultivation of pediatric pathology talents, the application of new technologies, clinical pathological diagnosis and research, as well as many other aspects over the past decade, and looks forward to the future development of pediatric pathology.
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