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Relationship Between the Gut Microbiome, Tryptophan-Derived Metabolites, and Osteoarthritis-Related Pain: A Systematic Review with Meta-Analysis.
Nutrients
January 2025
Grupo de Investigación en Calidad de Vida y Salud, Departamento de Ciencias de la Salud, Universidad Europea de Valencia, 03016 Alicante, Spain.
Introduction: Osteoarthritis (OA) is the most prevalent form of arthritis and affects over 528 million people worldwide. Degenerative joint disease involves cartilage degradation, subchondral bone remodeling, and synovial inflammation, leading to chronic pain, stiffness, and impaired joint function. Initially regarded as a "wear and tear" condition associated with aging and mechanical stress, OA is now recognized as a multifaceted disease influenced by systemic factors such as metabolic syndrome, obesity, and chronic low-grade inflammation.
View Article and Find Full Text PDFA 21st-century update of Claude Bernard's Theory about the Constancy of the Internal Environment.
Neuropsychopharmacol Hung
December 2024
Municipal Clinic of Szentendre, Internal Medicine, Szentendre, Hungary.
Article Synopsis
- The understanding of ion compartments and cell membrane functions leads to insights into intracellular ions and their roles in health, especially concerning the regulation of carbon dioxide levels as a vital signaling molecule.
- Chronic stress alters ion patterns, influencing conditions like Metabolic Syndrome and mental disorders, highlighting the connection between ion balance and overall health.
- To maintain well-being and potentially extend lifespan, it's crucial to preserve the original ion pattern through proper ventilation and possibly the administration of specific ion salts.
The anthelmintic activity of the white wormwood (Artemisia herba Alba) against Haemonchus contortus in beef cattle.
Sci Rep
January 2025
Department of Agriculture, Women's University in Africa, 549 Arcturus Road, Harare, Zimbabwe.
The objective of the study was to determine the efficacy of white wormwood on helminthes in beef cattle production. Water extracts of white wormwood of different levels of phytotoxicity were used to treat female adult H. contortus over 8 h under controlled laboratory conditions.
View Article and Find Full Text PDF"The soul that goes to the doctors does not live:" disease and illness among nineteenth-century Russian peasants.
Hist Cienc Saude Manguinhos
December 2024
Leading scientific researcher, Ural Federal University. Yekaterinburg - Russian Federation
The article deals with the representation of illness among Russian Orthodox peasants from the Russian Empire in the nineteenth century. Materials from ethnographic expeditions, folklore, nineteenth-century texts on treatments, memoirs, and publications in the local press are used as sources. Analysis of the sources allowed us to reach the following conclusions: the conception of illness among Russian peasants was constructed by various actors; rural doctors were the least influential among these actors; and illnesses were represented as a consequence of mixing the world of the living and the world of the dead or the action of anthropomorphic or zoomorphic entities, with treatment implying a return to the natural ("correct") order of things.
View Article and Find Full Text PDFEmpagliflozin and the Risk of Retinopathy in Patients With Type 2 Diabetes.
JAMA Ophthalmol
January 2025
Department of Medicine, Division of Pharmacoepidemiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Article Synopsis
- Empagliflozin may reduce the risk of diabetic retinopathy (DR) by preventing the loss of retinal pericytes, but its effectiveness compared to DPP4 inhibitors in patients with type 2 diabetes (T2D) is not well established.
- A study was conducted using U.S. insurance claims data from 2014 to 2019, focusing on adults with T2D who were newly prescribed either empagliflozin or a DPP4 inhibitor, and looking at the incidence of nonproliferative DR and its progression.
- Results showed that among matched patient pairs, empagliflozin's impact on the rates of incident DR and progression was analyzed, with significant data collected over an average
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