The effect of zinc and the combined effect of zinc and lead on the Ala-D of the erythrocytes were experimentally followed in vivo and vitro. It was demonstrated that the zinc effect on the Ala-D is a function of the zinc-concentrate in blood. It was hence traced that ZnCl2 dosis up to 500 mug/ml blood raises the activity of Ala-D. Higher levels of ZnCl2 on other side leads to supression of the Ala-D activity. The experiments demonstrated further zinc exerts a dosis dependent antagonistic effect on the lead suppression of the Ala-D. Possible explanations of the effect of zinc on the Ala-D, and the antagonistic zinc effect after lead applications are still in discussion.
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