The reasons are discussed why Leonardo da Vinci is being overestimated as engineer and inventor, although the majority of his drawings concerning engineering are not beyond the level of contemporary engineering knowledge and he never attempted to carry out those which would have been novel in fact.
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Cancer Lett
January 2025
Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China, 210029; The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, Jiangsu Province, China. Electronic address:
Preoperative detection of muscle-invasive bladder cancer (MIBC) remains a great challenge in practice. We aimed to develop and validate a deep Vesical Imaging Network (ViNet) model for the detection of MIBC using high-resolution Tweighted MR imaging (hrTWI) in a multicenter cohort. ViNet was designed using a modified 3D ResNet, in which, the encoder layers were pretrained using a self-supervised foundation model on over 40,000 cross-modal imaging datasets for transfer learning, and the classification modules were weakly supervised by an experiential knowledge-domain mask indicated by a nnUNet segmentation model.
View Article and Find Full Text PDFScand J Gastroenterol
January 2025
Department of Clinical Sciences Lund, Surgery, Lund University.
Objectives: The only treatment with curative potential for distal cholangiocarcinoma (dCCA) is radical surgery which can be complemented with adjuvant chemotherapy. The aim of the present study was to perform an independent external validation of a prognostic model for 3-year overall survival based on routine clinicopathological variables for patients treated with pancreatoduodenectomy for dCCA.
Materials And Methods: All patients with a histopathological confirmed dCCA that underwent pancreatoduodenectomy in Sweden from 2009 through 2019 were identified in the Swedish National Registry for Pancreatic and Periampullary Cancer.
Sci Rep
January 2025
NPSY.Lab-VR, Department of Human Sciences, University of Verona, Lungadige Porta Vittoria 17, Verona, Italy.
The Economy of action hypothesis postulates that bodily states rescale the perception of the individual's environment's spatial layout. The estimation of distances and slopes in navigation space (i.e.
View Article and Find Full Text PDFCognition
January 2025
Department of Psychology, University of Waterloo, Waterloo, ON, Canada.
How do we infer the beliefs of an entire group (e.g., Democrats) after being exposed to the beliefs of only a handful of group members? What if we know that the beliefs we encountered were selected in a biased manner? Across two experiments, we recruited 640 U.
View Article and Find Full Text PDFPhys Med Biol
January 2025
Schlegel Research Institute for Aging, University of Waterloo, 250 Laurelwood Drive, Waterloo, Ontario, N2L 3G1, CANADA.
As ultrasound-compatible flow phantoms are devised for performance testing and calibration, there is a practical need to obtain independent flow measurements for validation using a gold-standard technique such as particle image velocimetry (PIV). In this paper, we present the design of a new dual-modality flow phantom that allows ultrasound and PIV measurements to be simultaneously performed. Our phantom's tissue mimicking material is based on a novel hydrogel formula that uses propylene glycol to lower the freezing temperature of an ultrasound-compatible poly(vinyl) alcohol cryogel and, in turn, maintain the solution's optical transparency after thermocycling.
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