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Evolution Driven Microscale Combinatorial Chemistry in Intracellular Mimicking Droplets to Engineer Thermostable RNA for Cellular Imaging.
Small
January 2025
School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Fluorescent light-up aptamer/fluorogen pairs are powerful tools for tracking RNA in the cell, however limitations in thermostability and fluorescence intensity exist. Current in vitro selection techniques struggle to mimic complex intracellular environments, limiting in vivo biomolecule functionality. Taking inspiration from microenvironment-dependent RNA folding observed in cells and organelle-mimicking droplets, an efficient system is created that uses microscale heated water droplets to simulate intracellular conditions, effectively replicating the intracellular RNA folding landscape.
View Article and Find Full Text PDFLong-term prediction for karst spring discharge and petroleum substances concentration based on the combination of LSTM and Transformer models.
Water Res
January 2025
College of Resources and Environmental Engineering, Guizhou University, Guiyang 550025, China.
Monitoring the quantity and quality of karst springs is essential for groundwater resource management. However, it is challenging to robustly forecast the karst spring discharge and pollutant concentration due to the high complexity and heterogeneity of karst aquifers. Few researchers have addressed the long-term prediction of hourly spring quantity and quality, which is crucial for emergency management.
View Article and Find Full Text PDFBiofiltration for odor mitigation in water resource recovery facilities.
Sci Total Environ
January 2025
Department of Civil Engineering, City College of New York, New York, NY 10031, United States.
Odor emissions, primarily from anthropogenic activities like waste treatment and industrial processes, pose significant challenges in urban areas, particularly near water resource recovery facilities. While these emissions are generally not toxic, they can adversely affect community wellbeing and investment, prompting stricter regulations in some regions. For example, New York State's hydrogen sulfide guidelines are more stringent than federal standards.
View Article and Find Full Text PDFDelivering Volumetric Hyperthermia to Head and Neck Cancer Patient-Specific Models Using an Ultrasound Spherical Random Phased Array Transducer.
Bioengineering (Basel)
December 2024
Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94115, USA.
In exploring adjuvant therapies for head and neck cancer, hyperthermia (40-45 °C) has shown efficacy in enhancing chemotherapy and radiation, as well as the delivery of liposomal drugs. Current hyperthermia treatments, however, struggle to reach large deep tumors uniformly and non-invasively. This study investigates the feasibility of delivering targeted uniform hyperthermia deep into the tissue using a non-invasive ultrasound spherical random phased array transducer.
View Article and Find Full Text PDFGreening but enhanced vegetation water stress in the Yellow River Basin: A holistic perspective.
J Environ Manage
January 2025
School of Water Conservancy and Transportation, Zhengzhou University, Zhengzhou, 450001, China; Water Resources Department, China Institute of Water Resources and Hydropower Research (IWHR), Beijing, 100038, China.
The Yellow River Basin (YRB) has emerged as a focal point of global vegetation greening due to climate change and human activities. Given its ecological vulnerability and intense human activities, environmental sustainability has become an urgent concern for scholars. Current research on the hydrological effects of vegetation greening, from a reductionist perspective, still struggle to answer the crucial question that whether vegetation water stress is increasing or decreasing.
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