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Effects of Rice Husk Ash Particle Size and Luxan Value Influence on Mortar Properties and Proposal of Hydration Ratio Measurement Method.
Materials (Basel)
December 2024
Department of Architecture, Faculty of Science and Technology, Tokyo University of Science, Noda City 278-8510, Japan.
A fundamental study has been conducted on the effective utilization of rice husk ash (RHA) in concrete. RHA is an agricultural byproduct characterized by silicon dioxide as its main component, with a content of 90% or more and a porous structure that absorbs water during mixing, thereby reducing fluidity. The quality of RHA varies depending on the calcination environment; however, the effect is not consistent.
View Article and Find Full Text PDFEffects of intra-tumoral cellular heterogeneity of oxygen partial pressure on biological effectiveness of hydrogen-, helium-, carbon-, oxygen-, and neon-ion beams.
Phys Med Biol
January 2025
Department of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
The tumor microenvironment characterized by heterogeneously organized vasculatures causes intra-tumoral heterogeneity of oxygen partial pressurepat the cellular level, which cannot be measured by current imaging techniques. The intra-tumoral cellularpheterogeneity may lead to a reduction of therapeutic effects of radiation. The purpose of this study was to investigate the effects of the heterogeneity on biological effectiveness of H-, He-, C-, O-, and Ne-ion beams for different oxygenation levels, prescribed dose levels, and cell types.
View Article and Find Full Text PDFAntitumor Activity of the PD-1/PD-L1 Inhibitor SCL-1 in Various Mouse Tumor Models.
In Vivo
December 2024
Immunotherapy Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan;
Background/aim: Immune checkpoint blockade has achieved great success as a targeted immunotherapy for solid cancers. However, small molecules that inhibit programmed death 1/programmed death ligand 1 (PD-1/PD-L1) binding are still being developed and have several advantages, such as high bioavailability. Previously, we reported a novel PD-1/PD-L1-inhibiting small compound, SCL-1, which showed potent antitumor effects on PD-L1 tumors.
View Article and Find Full Text PDFHazard rates of recurrence for gastric cancer after curative resection: implications for postoperative surveillance.
Gastric Cancer
December 2024
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi Ward, Yokohama, Kanagawa, 241-8515, Japan.
Background: Identifying the most effective postoperative surveillance interval in patients with gastric cancer (GC) remains challenging. To elucidate a logical and effective surveillance schedule, we analyzed GC recurrence risk trends after gastrectomy using the hazard function.
Methods: We retrospectively reviewed the medical records of 2503 patients who underwent curative GC resection between 2000 and 2018.
Evaluation of Soil Antagonism against the White Root Rot Fungus Rosellinia necatrix and Pathogen Mycosphere Communities in Biochar-amended Soil.
Microbes Environ
December 2024
Institute for Plant Protection, National Agriculture and Food Research Organization (NARO).
White root rot disease caused by Rosellinia necatrix is a growing issue in orchards, and biochar pyrolyzed from the pruned branch residues of fruit trees has potential as a soil amendment agent with a number of benefits, such as long-term carbon sequestration. However, the effects of pruned branch biochar on white root rot disease remain unclear. Therefore, we compared direct antagonism against R.
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