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Genetic susceptibility of diffuse large B-cell lymphoma: a meta genome-wide association study in Asian population.
Leukemia
December 2024
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, Guangdong, China.
Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy and the most common form of non-Hodgkin lymphoma (NHL) that occurs worldwide. To discover risk factors and pathogenesis of DLBCL, we performed the largest GWAS of DLBCL to date in samples of East Asian ancestry, consisting of 2,888 patients with DLBCL and 12,458 controls. The meta-analysis identified three novel loci, rs2233434 on 6p21.
View Article and Find Full Text PDFAPASL clinical practice guidelines on systemic therapy for hepatocellular carcinoma-2024.
Hepatol Int
December 2024
Department of Gastroenterology, Yamanashi Prefectural Center Hospital, Kofu-City, Yamanashi, Japan.
Article Synopsis
- * Recent advancements in targeted therapy and immune-checkpoint inhibitors are now becoming available for treating unresectable HCC and preventing recurrence after curative procedures.
- * This clinical practice guideline aims to provide updated recommendations from Asia-Pacific experts on systemic therapy for HCC, addressing key questions about patient selection, effective treatments, and management strategies for immunotherapy.
Accelerated cognitive aging in chronically infected HIV-1 positive individuals despite effective long-term antiretroviral therapy.
Metab Brain Dis
November 2024
Department of Virology and Biotechnology, ICMR-National Institute for Research in Tuberculosis, Chennai, 600031, India.
Article Synopsis
- * A study conducted in Chennai found that 71% of virally suppressed PLHIV showed significant neurocognitive impairment, despite long-term adherence to antiretroviral therapy and undetectable viral loads.
- * The research revealed changes in proteins and metabolites linked to neuroinflammation and cognitive decline, emphasizing the need for targeted intervention strategies for improving long-term management of HIV-infected individuals.
Management of Patients with Advanced Prostate Cancer. Report from the 2024 Advanced Prostate Cancer Consensus Conference (APCCC).
Eur Urol
October 2024
Onkozentrum Zurich, University of Zurich and Tumorzentrum Hirslanden Zurich, Zurich, Switzerland.
Article Synopsis
- Innovations in advanced prostate cancer have improved outcomes, but there's still a lack of high-level evidence in clinical management, prompting the 2024 Advanced Prostate Cancer Consensus Conference to survey experts for insights.
- A panel of 120 international experts developed and voted on 183 consensus questions through a web-based survey prior to the conference, defining consensus as ≥75% agreement.
- The voting results highlight areas of agreement and disagreement that can guide clinical decisions and future research, with a focus on individualizing treatment based on patient characteristics and encouraging participation in clinical trials.
Correction to: Daratumumab, bortezomib, melphalan, and prednisone versus bortezomib, melphalan, and prednisone alone in transplant-ineligible Asian patients with newly diagnosed multiple myeloma: final analysis of the phase 3 OCTANS study.
Ann Hematol
November 2024
Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
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