Charles Edouard Brown-Séquard used observation of recovered patients and experimental animals to support his theory of cerebral localization. Recovery theories assume that the nervous system is composed of one organ or many, and that each organ has one function or many. From his own studies as well as others, Brown-Séquard concluded that the brain contained at least nine separate organs, each with a single distinct function, and that each organ is organized, not as a geographically isolated cluster of neurons, but as a widely disseminated network. According to his view, function is not uniformly distributed in an organ. Focal necrosis of part of an organ temporarily inhibits the action of distant, undamaged parts; resolution of this inhibition results in recovery. Using this theory of cerebral localization and recovery, Brown-Séquard practiced an early form of scientific neurology.
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http://dx.doi.org/10.1080/09647049609525649 | DOI Listing |
Alzheimers Dement
December 2024
University Hospital RWTH Aachen, Aachen, NRW, Germany.
Background: Physical exercise presents a viable low-cost, low-risk, individual, and widely available non-pharmacological treatment candidate in cognitive decline such as in Alzheimer's disease (AD). There are even indications that it can reduce the risk of developing dementia in the first place (Livingston et al., The Lancet, 2020).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Background: The cognitive reserve (CR) theory seeks to explain the mismatch often reported between brain damage and its clinical expression. Unlike most previous studies that focused on individuals with memory deterioration before the diagnosis of Alzheimer's disease (AD), the present study examined the late stages of the disease. The study sought to confirm the hypothesis that patients with higher CR are diagnosed later and decline faster than those with lower CR because their brain pathology is more severe.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: Black Americans (BAs), Hispanics/Latinos (H/Ls), and Africans (As) face a disproportionate burden of aging and Alzheimer's Disease and Related Dementias (AD/ADRD), coupled with underrepresentation in research. Further, researchers also report a lack of compliance on sensitive social determinants of health data for AD/ADRD research. For instance, the PRAPARE tool reports a low completion rate in community and clinical settings.
View Article and Find Full Text PDFSmall
January 2025
Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas, Vassilika Vouton, Heraklion, 70013, Greece.
Metal halide perovskites (MHPs) have attracted significant attention owing to their simple manufacturing process and unique optoelectronic properties. Their reversible electrical or optical property changes in response to oxidizing or reducing environments make them prospective materials for gas detection technologies. Despite advancements in perovskite-based sensor research, the mechanisms behind perovskite-gas interactions, vital for sensor performance, are still inconclusive.
View Article and Find Full Text PDFJ Affect Disord
January 2025
Mondor University Hospitals, INSERM U955, Institut Mondor de La Recherche Biomédicale (IMRB), University of Paris Est Créteil, Équipe Neuropsychiatrie Translationnelle, Créteil, France; NeuroSpin, Neuroimaging Platform, CEA, UNIACT Lab, PsyBrain Team, Saclay, France. Electronic address:
Transcranial Direct Current Stimulation (tDCS) has shown potential in modulating cortical activity and treating depression. Despite its promise, variability in electrode montage configurations and electric field strength across studies has resulted in inconsistent outcomes. Traditional meta-analytic methods assessing the effect of tDCS in depression typically do not compare tDCS montage and the anatomical distribution of electric field, which is a major source of inter-experimental variability.
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