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Pharmacogenetic Testing in Admixed Populations: Frequency of the AMR PGx Working Group Tier 1 Variant Alleles in Brazilians.
J Mol Diagn
January 2025
Clinical Research and Technological Development Division (Divisão de Pesquisa Clínica e Desenvolvimento Tecnológico), Brazilian National Cancer Institute (Instituto Nacional de Câncer), Rio de Janeiro, Brazil. Electronic address:
This article examines the frequency distribution of Tier 1 pharmacogenetic variants of the Association for Molecular Pathology Pharmacogenomics Working Group Recommendations in two large (>1.000 individuals) cohorts of the admixed Brazilian population, and in patients from the Brazilian Public Health System enrolled in pharmacogenetic trials. Three Tier 1 variants, all in DPYD, were consistently absent, which may justify their non-inclusion in genotyping panels for Brazilians; 13 variants had frequency < 1.
View Article and Find Full Text PDFThe use of multiple evidence base methods to enrich climate change research and knowledge in the Arctic.
Ambio
January 2025
Department of Arctic and Marine Biology, UiT Arctic University of Norway, Alta, Norway.
Indigenous and local knowledge (ILK) is increasingly used along with scientific knowledge (SK) to understand climate change. The multi evidence base (MEB) offers ways of combining knowledge systems together. Nonetheless, there is little guidance on how to use MEB approaches in research.
View Article and Find Full Text PDFDiabetes Management Using a Patient Navigator in a Native Hawaiian Population: Experiences and Perceptions of the Kilolani Project.
Int J Environ Res Public Health
January 2025
The Queen's Health System, Honolulu, HI 96813, USA.
Native Hawaiians (NHs) are a historically oppressed population disproportionately burdened by diabetes and related complications. The Kilolani Project, a patient navigator-centered, chronic disease management program, targets upstream drivers of health among vulnerable NH adult patients with diabetes within an urban academic safety-net clinic. To investigate the impact of the Kilolani Project, we performed a qualitative study to examine patient perspectives.
View Article and Find Full Text PDFSupporting Holistic Health and Gestational Diabetes Mellitus Risk Reduction Among Young Native Females Prior to Pregnancy: A Qualitative Exploration.
Int J Environ Res Public Health
December 2024
Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
AI/AN communities are disproportionately impacted by food insecurity and gestational diabetes mellitus (GDM). Decreasing the risk of GDM can interrupt the intergenerational cycle of diabetes in AI/AN families, and can decrease diabetes-related health disparities. The goal of this study was to explore ways of supporting holistic health and reducing the risk of GDM among young American Indian and Alaska Native (AI/AN) females prior to pregnancy.
View Article and Find Full Text PDFEffects of socioeconomic and human-modified landscape variables on medicinal species richness at a macroscale: the case of the Caatinga, Brazil.
J Ethnobiol Ethnomed
January 2025
Programa de Pós-Graduação em Etnobiologia e Conservação da Natureza, Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil.
Background: Ethnobiological studies at local scales have shown that knowledge of medicinal species tends to decrease as socioeconomic status and the extent of human-modified landscapes increase. However, it remains largely unknown whether these same factors can predict knowledge of useful species at broader scales and whether their interaction might create scenarios that enhance knowledge of medicinal species.
Methods: To address this, we tested whether knowledge of woody medicinal species-measured as the number of species known-is influenced by socioeconomic status, human-modified landscapes, and their interaction.
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