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Cardiovascular complications in vascular connective tissue disorders after COVID-19 infection and vaccination.
PLoS One
December 2024
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Background: COVID-19 infection and vaccination have been reported to confer an elevated risk for cardiovascular events (CVE). We sought to determine whether individuals with an underlying vascular connective tissue disorder including Marfan syndrome (MFS), Loeys-Dietz syndrome (LDS), or vascular Ehlers Danlos syndrome (vEDS) are at increased risk for cardiac events after COVID-19 infection or vaccination.
Methods: 325 respondents self-reported data through a cross-sectional, web-based survey available from 22 November 2021, through 15 March 2022 regarding COVID-19 illness and vaccinations, the occurrence of any CVE, and adverse events following vaccination.
Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C).
J Exp Med
December 2024
Section of Paediatric Infectious Disease, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, "burdenMC," which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.
View Article and Find Full Text PDFEvaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial.
Emerg Microbes Infect
December 2025
Integrated Research Facility at Fort Detrick (IRF-Frederick), National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Fort Detrick, Frederick, MD, USA
rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination.
View Article and Find Full Text PDFChanges to virus taxonomy and the ICTV Statutes ratified by the International Committee on Taxonomy of Viruses (2024).
Arch Virol
November 2024
The Biodesign Center for Fundamental and Applied Microbiomics, School of Life Sciences, Center for Evolution and Medicine, Arizona State University, Tempe, AZ, 85287-4701, USA.
Article Synopsis
- The article outlines recent updates to virus taxonomy approved by the International Committee on Taxonomy of Viruses (ICTV) in April 2024.
- The ICTV invited members to vote on 203 taxonomic proposals, resulting in significant additions across various levels, including one new phylum and 3,547 new species.
- The total number of established virus species now stands at 14,690, following the ratification of proposals for species name formatting to the binomial system.
Phosphorylation of P-stalk proteins defines the ribosomal state for interaction with auxiliary protein factors.
EMBO Rep
December 2024
Department of Molecular Biology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin, Poland.
Article Synopsis
- Ribosomal function is enhanced by trans-acting factors and ribosomal elements, with phosphorylation playing a key regulatory role.
- The ribosomal P-stalk, which consists of five phosphorylated C-terminal domains, activates translational GTPases and connects to the Gcn2 kinase within the integrated stress response (ISR) pathway.
- Unlike most ribosomal proteins, P-stalk proteins remain in a constantly phosphorylated state, promoting optimal translation efficiency and allowing flexible interaction with various protein partners.
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