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Advancements in bispecific antibodies for multiple myeloma: What's new and what lies ahead.
Semin Hematol
December 2024
Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:
Recent advancements in multiple myeloma (MM) treatment-including immunomodulatory drugs, proteasome inhibitors, monoclonal antibodies, and T cell-redirecting therapies like chimeric antigen receptor (CAR) T cells and bispecific antibodies (BsAbs)-have significantly improved patient outcomes. However, MM remains incurable, highlighting the need for novel therapeutic strategies. BsAbs, which simultaneously target a tumor-specific antigen and CD3 on T cells, have shown promising efficacy.
View Article and Find Full Text PDFAssessment of Opuntia ficus-indica supplementation on enhancing antioxidant levels.
Sci Rep
January 2025
School of Healthy Aging, Aesthetic and Regenerative Medicine, Faculty of Medicine and Health Sciences, UCSI University, 56000, Cheras, Kuala Lumpur, Malaysia.
Opuntia ficus-indica (OFi) is a major fruit source prevalent in semiarid and arid regions across various countries worldwide. It is widely recognised for its potential health benefits; however, most studies investigating its effects have been limited to pre-clinical models, highlighting the need for further validation through clinical trials. This study aimed to evaluate the effectiveness of OFi supplementation in enhancing antioxidant levels.
View Article and Find Full Text PDFNavigating through chemometrics: Unveiling antibiotic-food interactions for improved pediatric formulations ahead.
Eur J Pharm Biopharm
January 2025
Background: Given the challenges of pediatric antibacterial therapy, it is crucial to formulate antibiotics with a lower potential for interaction with dietary interventions and tailor them for optimal administration in children. Chemometric methods allow us to analyze multiple interrelated variables simultaneously and uncover correlations.
Aim: We applied a chemometric approach to examine how food, beverages, antacids, and mineral supplements affect antibiotic bioavailability in adults and children, aiming to explore relationships between antibiotic structure, physicochemical properties, and post-meal changes in pharmacokinetic (PK) parameters.
Development and application of an efficient, accurate, and environmentally friendly liquid chromatography-tandem mass spectrometry method for the determination of five Alternaria toxins in wheat.
Food Chem X
January 2025
Academy of National Food and Strategic Reserves Administration, NFSRA Key Laboratory of Grain and oil quality and safety, Beijing 100037, China.
The contamination of Alternaria toxins poses a potential risk to human health. This study developed a rapid, efficient, and environmentally friendly method for the simultaneous determination of five types of Alternaria toxins in wheat using high-precision and stable isotope liquid chromatography tandem mass spectrometry. The comparison between dilution method and solid-phase extraction method shows that the former achieves satisfactory results with a simple and convenient sample purification method.
View Article and Find Full Text PDFβ-ecdysone/PLGA composite scaffolds promote skull defect healing in diabetic rat.
Front Bioeng Biotechnol
January 2025
Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, College and Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China.
Introduction: Diabetes mellitus often leads to bone metabolism disorders, hindering bone regeneration and delaying the healing of bone defects. β-Ecdysone, a plant-derived hormone known for its wide range of physiological activities, possesses hypoglycemic effects and promotes osteogenic differentiation. This study developed a composite PLGA slow-release scaffold loaded with β-ecdysone to enhance its bioavailability through topical administration and to investigate its potential to heal diabetic bone defects.
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