The effects of unilateral transection of bulbar pyramids on instrumental conditioned reflexes in rats were shown to be in direct relationship with the time of its execution. In rats with stable conditioned reflexes, pyramidotomy impaired conditioned performance, on the average, for 3.9 days. However, preliminary transection of the pyramid delayed operant conditioning and its stabilization, on the average, by 16.5 day. The findings are discussed in terms of the mechanisms of switching over descending influences of the cortico-spinal and cortico-rubrospinal systems.
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