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| http://dx.doi.org/10.1136/ard.60.11.1058 | DOI Listing |
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Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu's arteritis.
Arthritis Res Ther
January 2025
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Background: Advances in treatment have swiftly alleviated systemic inflammation of Takayasu's arteritis (TAK), while subclinical vascular inflammation and the ensuing arterial remodeling continue to present unresolved challenges in TAK. The phenotypic switching of vascular smooth muscle cells (VSMC) is regarded as the first step in vascular pathology and contributes to arterial remodeling. Exosomes facilitate the transfer and exchange of proteins and specific nucleic acids, thereby playing a significant role in intercellular communication.
View Article and Find Full Text PDFThe Current and Novel Imaging Modalities for Ocular Vasculitis in Behcet's Disease: A Review.
Cureus
September 2024
Division of Rheumatology, Department of Internal Medicine, Wyckoff Heights Medical Center, Brooklyn, USA.
Behcet's syndrome is a multisystem inflammatory disorder characterized by a chronic relapsing course and diverse clinical manifestations, prominently affecting young adults along the ancient Silk Road and beyond. The disease pathogenesis involves complex interactions between genetic predisposition, environmental triggers, and dysregulated immune responses, leading to systemic vasculitis and tissue damage. Ocular involvement, a hallmark of Behcet's Disease (BD), significantly impacts morbidity, with uveitis as a common initial presentation that can progress to severe vision-threatening complications like retinal vasculitis and occlusive disease.
View Article and Find Full Text PDFInflammation of the temporalis muscle and adjacent nerve tissue in giant cell arteritis: expanding the spectrum of inflammatory lesions.
Rheumatology (Oxford)
October 2024
Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany, Berlin.
Objectives: To investigate the histopathological features of the temporalis muscle (TM) and adjacent nerve tissue in active cranial giant cell arteritis (C-GCA).
Methods: Temporal artery biopsy (TAB) specimens containing fragments of the TM from patients with active C-GCA fulfilling the 2022 ACR/EULAR classification criteria (n = 11) were assessed by conventional histology and immunohistochemistry in comparison with non-GCA controls (n = 3). Clinical, laboratory and imaging features based on patient charts at time of biopsy were retrospectively recorded.
Encephalomyelitis and serositis caused by in buffalo calves from Brazil.
Vet Pathol
October 2024
Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
Article Synopsis
- The text discusses a subclinical infection in cattle that occasionally leads to cases of bovine encephalomyelitis, particularly in calves and European buffalo.
- An outbreak in Brazil affected 3-month-old buffalo calves, showing symptoms like incoordination and depression, ultimately resulting in death.
- Necropsies revealed severe brain and heart abnormalities along with specific immune responses, while tests showed no pathogenic bacteria present, confirming the disease through PCR.
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