AI Article Synopsis
- Drug combinations have been researched to combat infections from bacteria like Pseudomonas and Acinetobacter.
- Time-kill analysis was used to assess how gatifloxacin (GAT) worked together with nonquinolone drugs at realistic dosage levels.
- Significant synergy in killing bacteria (more than a 2 log(10) reduction after 24 hours) was found when GAT was paired with either amikacin or beta-lactams in 50 to 75% of strains tested, including those resistant to one or both drugs.
Article Abstract
Drug combinations have been used to treat serious infections caused by Pseudomonas, Burkholderia, Stenotrophomonas, and Acinetobacter. In this study, the combined drug effects of gatifloxacin (GAT) and nonquinolones were determined by time-kill analysis at clinically achievable drug concentrations. Synergy (>or=2 log(10)-enhanced killing at 24 h) was observed with GAT plus amikacin or a beta-lactam against 50 to 75% of strains, including strains nonsusceptible to one or both drugs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC90810 | PMC |
| http://dx.doi.org/10.1128/AAC.45.11.3220-3222.2001 | DOI Listing |
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