AI Article Synopsis
- Urologists often use intravenous dyes like methylene blue and indigo carmine to diagnose genitourinary issues and check ureteral function.
- Two patients were reported who did not show methylene blue in their urine after it was injected, despite having normal kidney function.
- This could be due to methylene blue converting to a colorless form (leukomethylene blue) during metabolism, while indigo carmine maintains its color and can be easily filtered by the kidneys, indicating a metabolic rather than an anatomical issue.
Article Abstract
Urologists use intravenous dyes in diagnosing genitourinary fistulas and in investigating ureteral patency. Methylene blue and indigo carmine are the most common dyes used today. Generally, patients with clinically normal renal function demonstrate dye in their urine after several minutes. We report on 2 patients in whom methylene blue was not visualized after intravenous injection. A review of urologic and pharmacologic published reports led to a possible explanation for this phenomenon. Methylene blue can metabolize into leukomethylene blue, which is colorless in urine. Indigo carmine, however, is not readily metabolized but is rather freely filterable by the kidneys. Therefore, it is important to appreciate that nonvisualization of methylene blue may be a metabolism effect and not an anatomic one.
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| http://dx.doi.org/10.1016/s0090-4295(01)01325-5 | DOI Listing |
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