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Purpose: Understanding the molecular mechanisms of adaptive regulation in the tumor microenvironment is crucial for precision therapy in hepatocellular carcinoma (HCC). We hypothesized that cargo proteins carried by extracellular vesicles (EVs) released in a hypoxic microenvironment might promote HCC progression by remodeling tumor-associated macrophages (TAMs).
Methods: EV protein analysis by label-free proteomics mass spectrometry of HCC cell lines of different tumor grades was performed.
The putative polyamine transporter Shp2 facilitates phosphate export in an Xpr1-independent manner and contributes to high phosphate tolerance.
J Biol Chem
December 2024
Faculty of Science and Engineering, Department of Biology, Konan University, Kobe, Japan; Institute of Integrative Neurobiology, Konan University, Kobe, Japan. Electronic address:
Phosphate (Pi) homeostasis at the cellular level is crucial, requiring coordinated Pi uptake, storage, and export. However, the regulatory mechanisms, particularly those governing Pi export, remain elusive, despite their relevance to human diseases like primary familial brain calcification. While Xpr1, conserved across eukaryotes, is the only known Pi exporter, the existence of additional Pi exporting factors is evident; however, these factors have been poorly characterized.
View Article and Find Full Text PDFBlocking adipocyte YY1 decouples thermogenesis from beneficial metabolism by promoting spermidine production.
Diabetes
December 2024
Department of Endocrinology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou 225300, China.
The accumulation of mitochondria in thermogenic adipose tissue (i.e., brown and beige fat) increases energy expenditure, which can aid in alleviating obesity and metabolic disorders.
View Article and Find Full Text PDFA Bis(Acridino)-Crown Ether for Recognizing Oligoamines in Spermine Biosynthesis.
Molecules
September 2024
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Szent Gellért Square 4, 1111 Budapest, Hungary.
Oligoamines in cellular metabolism carry extremely diverse biological functions (i.e., regulating Ca-influx, neuronal nitric oxide synthase, membrane potential, Na, K-ATPase activity in synaptosomes, etc.
View Article and Find Full Text PDFStructural insights into polyamine spermidine uptake by the ABC transporter PotD-PotABC.
Sci Adv
September 2024
School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
Article Synopsis
- * The PotD-PotABC protein complex is a specific transporter system that helps bacteria take up spermidine, characterized as part of the ATP-binding cassette transporter family.
- * The study reveals key structural details of the PotD-PotABC transporter, highlighting its different conformations and specific residues that regulate the uptake of spermidine, enhancing our understanding of how this process occurs in bacteria.
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