We showed previously that transcription of a plasmid-borne kan allele increases C-to-T mutations in the nontranscribed strand. Using two new plasmid-borne kan alleles, one cmp allele, and a chromosomal kan allele, we found in this study that transcription-induced mutations are not limited to specific genes, alleles, or locations and are likely to be a general property of transcript elongation in Escherichia coli.
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| http://dx.doi.org/10.1128/JB.183.21.6491-6493.2001 | DOI Listing |
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