Models are developed that allow the effect of beta-lactam antibiotics on the level of apoptosis in human lymphoid cells to be evaluated in vitro. The antibiotics produced a dose-dependent decrease in apoptosis of mature lymphocytes both under normal conditions and in the state of dexamethasone-induced immunodepression. The beta-lactam antibiotics also affect the apoptosis in a pre-B-lymphoblast model. The dexamethasone-induced apoptosis is inhibited by beta-lactam antibiotics only in high doses.
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