Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2527/jas1975.412647x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Safety, Tolerability, and Pharmacokinetics of NIM-1324 an Oral LANCL2 Agonist in a Randomized, Double-Blind, Placebo-Controlled Phase I Clinical Trial.
Clin Transl Sci
January 2025
NIMML Institute, Blacksburg, Virginia, USA.
NIM-1324 is an oral investigational new drug for autoimmune disease that targets the Lanthionine Synthetase C-like 2 (LANCL2) pathway. Through activation of LANCL2, NIM-1324 modulates CD4+ T cells to bias signaling and cellular metabolism toward increased immunoregulatory function while providing similar support to phagocytes. In primary human immune cells, NIM-1324 reduces type I interferon and inflammatory cytokine (IL-6, IL-8) production.
View Article and Find Full Text PDFEvaluation of Plasma microRNA-222 as a Biomarker for Gastric Cancer.
J Clin Med
December 2024
Department of Surgery, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura 285-8741, Chiba, Japan.
The dysregulation of microRNAs (miRNAs) has been detected in patients with gastric cancer (GC), which inspired the use of miRNAs as a novel biomarker for GC. In this study, we investigated the previously reported miRNA dysfunction in cancer tissues as a potential plasma biomarker for GC using quantitative reverse transcriptase polymerase chain reaction (RT-PCR). The published miRNA abnormalities were searched in the microRNA Cancer Association Database.
View Article and Find Full Text PDFAnimal as the Solution II: Phenotyping for Low Milk Urea Nitrogen A1PF Dairy Cows.
Animals (Basel)
December 2024
Department of Agricultural Sciences, Faculty of Agricultural and Life Sciences, Lincoln University, Lincoln, P.O. Box 85084, Christchurch 7647, New Zealand.
The societal pressure on intensive pastoral dairying demands the search for strategies to reduce the amount of N flowing through and excreted by dairy cows. One of the strategies that is being currently explored focuses on the animal as a solution, as there are differences in N metabolism between cows even within the same herd. This work was conducted to explore such an approach in A1PF herds in New Zealand and the possibility of identifying A1PF cows that are divergent for milk urea nitrogen (MUN) concentration through phenotyping as a potential viable strategy to reduce N leaching and emissions from temperate dairy systems.
View Article and Find Full Text PDFComparative efficacy and safety of sitagliptin or gliclazide combined with metformin in treatment-naive patients with type 2 diabetes: A single-center, prospective, randomized, controlled, noninferiority study with genetic polymorphism analysis.
Medicine (Baltimore)
January 2025
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Background: This study evaluates the efficacy and safety of sitagliptin versus gliclazide, combined with metformin, in treatment-naive patients with type 2 diabetes mellitus (T2DM) and glucotoxicity.
Methods: In this single-center, randomized, controlled noninferiority trial, 129 treatment-naive patients with T2DM with glucotoxicity (fasting plasma glucose [FPG] ≥ 200 mg/dL and glycated hemoglobin ≥ 9.0%) were randomized to receive sitagliptin plus metformin (n = 66) or gliclazide plus metformin (n = 63) for 12 weeks.
Effects of including a palmitic acid-enriched supplement in low and high starch diets on milk production and energy partitioning of primiparous and multiparous dairy cows between mid and late-lactation.
J Dairy Sci
January 2025
Department of Animal Science, Michigan State University, East Lansing, MI 48824. Electronic address:
The aim of our study was to assess the effects of low or high-starch diets with or without palmitic acid (C16:0) supplementation on the yield of milk, milk components, and energy partitioning of primiparous and multiparous dairy cows between mid and late-lactation. Thirty-two Holstein cows, 12 primiparous ([mean ± SD] 163 ± 33 d in milk) and 20 multiparous ([mean ± SD] 179 ± 37 d in milk), were used in a split-plot Latin square design. Parity was considered the main plot, and within each plot, treatments were then randomly assigned in a replicated 4 × 4 Latin square with 21 d periods and balanced for carryover effects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!