AI Article Synopsis
- Benzodiazepines, tricyclic antidepressants, and local anesthetics are commonly linked to poisoning and fatalities, prompting the need for effective identification methods.
- A new procedure using solid-phase micro-extraction (SPME) and gas chromatography-mass spectrometry has been developed to quickly and accurately identify and quantify these drugs in postmortem samples.
- The optimal SPME fiber coating was determined to be polyacrylate, with testing showing high recovery and low variance in results across different days.
Article Abstract
Benzodiazepines, tricyclic antidepressants and local anaesthetics are frequently involved in poisoning episodes and fatalities. A specific, sensitive and rapid procedure for identifying and quantifying such drugs in postmortem matrices has been developed using solid-phase micro-extraction (SPME) and gas chromatography-mass spectrometry. Very clean extracts were obtained in one step using SPME. The most commonly used fibre coatings were tested to select the best coating for SPME of the drugs. The appropriate fibre coating for most drugs was polyacrylate, followed by Carbowax-divinylbenzene. A Hewlett-Packard 5890 gas chromatograph in combination with a Trio 2000 mass spectrometer was used to analyse the samples. Temperature, time, pH and addition of sodium chLoride were optimized to obtain consistent extraction. The between-day and within-day coefficients of variation were less than 16% and less than 6%, respectively.
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| http://dx.doi.org/10.1177/000456320103800512 | DOI Listing |
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