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Fire cupping inspired negative-pressure microneedle syringes loaded with herb berberine-based nano composite for psoriasis therapy.
Biomater Adv
March 2025
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330088, China; The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang 330088, China. Electronic address:
Psoriasis, an immune-mediated chronic inflammatory skin disorder, poses challenges for topical treatment due to the thickening of the stratum corneum, hindering drug penetration. Furthermore, long-term use of chemical drugs may lead to immunosuppression and abnormal hepatic or renal dysfunction. Inspired by traditional Chinese fire cupping (Ba Huo Guan), a negative-pressure microneedle syringe therapy has been proposed here for psoriasis treatment.
View Article and Find Full Text PDFA systematic review of the role of interleukin-17 inhibitors in bullous pemphigoid: therapeutic and paradoxical effects.
Arch Dermatol Res
March 2025
Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, 1199663911, Iran.
Bullous pemphigoid (BP) is the most common autoimmune-driven blistering disease. The incidence of BP has been rising due to population aging and exposure to medications such as biologics. Moreover, biologics are utilized as therapeutic choices for BP treatment as they inhibit cytokines and disrupt pathogenesis pathways.
View Article and Find Full Text PDFEffect of spesolimab on sustained disease control in patients with generalized pustular psoriasis: Post hoc analysis of the EFFISAYIL 2 study.
J Am Acad Dermatol
March 2025
Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:
Background: Generalized pustular psoriasis (GPP) is a chronic inflammatory disease with an unpredictable disease course. Long-term treatment goals include sustained resolution of skin symptoms, prevention of new flares, and improvement in quality of life (QoL).
Objective: To compare the effect of the interleukin-36 receptor monoclonal antibody spesolimab 600 mg subcutaneous (SC) loading dose (LD) followed by 300 mg SC every 4 weeks (q4w) versus placebo on skin symptoms and QoL burden in patients with GPP.
Efficacy of mesenchymal stem cell transplantation therapy to mitigate psoriasis: A systematic review and meta-analysis.
Curr Res Transl Med
March 2025
Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Uppal Road, Tarnaka, Hyderabad - 500007 TS, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad - 201002, India. Electronic address:
Psoriasis is a chronic inflammatory skin disease characterized by red lesions and skin patches with silvery scales. Overall, 2 - 3 % of the worldwide population is affected by psoriasis. Recent treatment strategies for psoriasis involve Mesenchymal stromal/stem cell (MSC) transplantation instead of conventional treatment with monoclonal antibodies and small molecule drugs.
View Article and Find Full Text PDFMinerals and Trace Elements: Key Protectors of Skin Health and Defenders Against Skin Disorders.
Curr Med Chem
March 2025
Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania.
Skin is the human body's largest organ, protecting it from various environmental threats. At the same time, it is the most accessible organ of the body, which ensures the reception of stimuli and contact with the environment. Such common signs of skin aging, such as wrinkles, fine lines, and discoloration, result from both extrinsic and intrinsic factors that act for a long time.
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