This report describes a new hamster model for West Nile (WN) virus encephalitis. Following intraperitoneal inoculation of a New York isolate of WN virus, hamsters had moderate viremia of 5 to 6 days in duration, followed by the development of humoral antibodies. Encephalitic symptoms began 6 days after infection; about half the animals died between the seventh and 14th days. The appearance of viral antigen in the brain and neuronal degeneration also began on the sixth day. WN virus was cultured from the brains of convalescent hamsters up to 53 days after initial infection, suggesting that persistent virus infection occurs. Hamsters offer an inexpensive model for studying the pathogenesis and treatment of WN virus encephalitis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631753 | PMC |
| http://dx.doi.org/10.3201/eid0704.010420 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of Probiotic Effects on the Growth Performance and Microbiome of Nile Tilapia () in a High-Density Biofloc System.
Aquac Nutr
January 2025
School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, Alabama 36849, USA.
Biofloc technology is an aquaculture production system that has gained popularity with tilapia production. Probiotics provide benefits for the host and/or aquatic environments by both regulating and modulating microbial communities and their metabolites. When a probiotic feed is combined with a biofloc system, the production amount may be improved through better fish growth, disease resistance, and/or improved water quality by reducing organic matter and stabilizing metrics such as pH and components of the nitrogen cycle.
View Article and Find Full Text PDFQuantifying West Nile virus circulation in the avian host population in Northern Italy.
Infect Dis Model
June 2025
Department of Mathematics, University of Trento, Trento, Italy.
West Nile virus (WNV) is one of the most threatening mosquito-borne pathogens in Italy where hundreds of human cases were recorded during the last decade. Here, we estimated the WNV incidence in the avian population in the Emilia-Romagna region through a modelling framework which enabled us to eventually assess the fraction of birds that present anti-WNV antibodies at the end of each epidemiological season. We fitted an SIR model to ornithological data, consisting of 18,989 specimens belonging to Corvidae species collected between 2013 and 2022: every year from May to November birds are captured or shot and tested for WNV genome presence.
View Article and Find Full Text PDFEfficient Detection of West Nile Virus in Urine Specimens by a Novel In-House RT-qPCR Detection Kit.
Can J Infect Dis Med Microbiol
January 2025
DESAM Research Institute, Near East University, Nicosia, Cyprus.
West Nile Virus (WNV) infection represents a major global public health challenge. Even though most of the patients are asymptomatic, some cases progress to critical condition which may be fatal. Diagnosis traditionally relies on serological methods, but their limitations, including cross-reactivity, highlight the need for alternative approaches.
View Article and Find Full Text PDFEcological risk factors for the establishment of West Nile virus in Britain.
Trends Parasitol
January 2025
UK Health Security Agency, Porton Down, UK.
West Nile virus (WNV) is a zoonotic mosquito-borne virus which is emerging across Europe, largely due to climate and other environmental changes. Detection of WNV at increasingly northern latitudes raises concern that WNV may be introduced to Britain, where ecological conditions could eventually support sustained transmission. Establishment of WNV depends on spatial and temporal overlap between infectious migratory birds and native vectors.
View Article and Find Full Text PDFOrthoflavivirus circulation in South-East Queensland, Australia, before and during the 2021-2022 incursion of Japanese encephalitis virus assessed through sero-epidemiological survey of a sentinel equine population.
One Health
December 2024
School of Chemistry and Molecular Biosciences, Faculty of Science, The University of Queensland, Brisbane, QLD 4072, Australia.
An incursion and outbreak of Japanese encephalitis virus (JEV) was reported in Australia in 2021 and 2022, respectively. There was speculation that JEV may have been circulating in Australia unknowingly prior to the detection. In this study, we determined sero-prevalence and transmission of West Nile virus (WNV), Murray Valley encephalitis virus (MVEV) and JEV, prior to and post JEV incursion in a sentinel equine population in south-east Queensland (SEQ), Australia, using blocking ELISAs (screening test) and virus neutralisation test (confirmatory).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!