The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and transfer steps, indicating that efficient virus transmission is not simply due to tethering of virus to the cell surface.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC114631 | PMC |
| http://dx.doi.org/10.1128/JVI.75.21.10523-10526.2001 | DOI Listing |
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