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Association of phenylalanine and tyrosine metabolism with mortality and response to nutritional support among patients at nutritional risk: a secondary analysis of the randomized clinical trial EFFORT.
Front Nutr
November 2024
Medical University Department, Division of General Internal and Emergency Medicine, Division of Endocrinology, Diabetes, and Metabolism, Kantonsspital Aarau, Aarau, Switzerland.
Background: Elevated phenylalanine serum level is a surrogate marker of whole-body proteolysis and has been associated with increased mortality in critically ill patients. Tyrosine is a metabolite of phenylalanine and serves as a precursor of thyroid hormones and catecholamines with important functions in the oxidative stress response among others. Herein, we examined the prognostic significance of phenylalanine, tyrosine, as well as its metabolites nitrotyrosine, L-3,4-dihydroxyphenylalanine (DOPA), and dopamine regarding clinical outcomes and response to nutritional therapy in patients at nutritional risk.
View Article and Find Full Text PDFAllograft Nerve Repair of a Transected Recurrent Laryngeal Nerve With Voice and Singing Recovery.
Laryngoscope
October 2024
Division of Plastic and Reconstructive Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, U.S.A.
Recurrent laryngeal nerve injuries can occur during thyroid and neck procedures or similar interventions. Immediate nerve repair when possible is preferred to both faciliate the repair and allow timely recovery of the muscle. Here, we report a case of transected left recurrent laryngeal nerve repaired by allograft nerve interposition with excellent return of speaking and singing voice with vocal cord function.
View Article and Find Full Text PDFAssessing the Quality of Care of Pregnant Patients With Thyrotoxicosis at an Urban Safety Net Hospital.
Endocr Pract
January 2025
Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, Massachusetts. Electronic address:
Objective: Thyrotoxicosis can adversely affect pregnancy. The quality of care (QoC) for thyrotoxicosis in pregnancy at a tertiary care safety net hospital was evaluated based on current guidelines.
Methods: Pregnant patients with thyrotoxicosis or a history of Graves disease who delivered in 2015-2021 were divided into 3 groups: low thyroid stimulating hormone (TSH), active Graves disease, and past Graves disease.
Hyolaryngeal Kinematics in Primary Muscle Tension Dysphonia Determined by Ultrasound.
J Voice
September 2024
Department of Communication Sciences and Disorders, Syracuse University, Syracuse, New York. Electronic address:
Objectives: The purpose of this study was to determine hyolaryngeal kinematics during voicing in people with primary muscle tension dysphonia (pMTD) compared with healthy speakers, and to investigate the relationships between hyolaryngeal displacement and self-perceived vocal function.
Methods: Twenty-six participants, 13 with pMTD and 13 healthy speakers, were assessed using sonography during sustained vowel phonation and rest. Displacement of the hyoid bone and thyroid cartilage was measured from still frames extracted from ultrasound video recordings, with measures normalized to reflect change from rest during voicing for each participant.
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