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Molecular machinery for non-vesicular trafficking of ceramide.
Nature
December 2003
Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Synthesis and sorting of lipids are essential for membrane biogenesis; however, the mechanisms underlying the transport of membrane lipids remain little understood. Ceramide is synthesized at the endoplasmic reticulum and translocated to the Golgi compartment for conversion to sphingomyelin. The main pathway of ceramide transport to the Golgi is genetically impaired in a mammalian mutant cell line, LY-A.
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Division of Nephrology, Medical School Hannover, Hannover, Germany.
Polyamine inhibition of the conversion of human proacrosin to acrosin.
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The conversion of human proacrosin to acrosin was inhibited by polyamines. The order of effectiveness was spermine greater than spermidine greater than cadaverine greater than putrescine greater than 1,3,-diaminopropane. These results are similar to those obtained for the conversion of boar proacrosin to acrosin.
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