Several patent disclosures were made on oxazolidinone, quinolone, macrolide and new antimicrobial agents between June and December 2000; 26 of these patents are discussed in this review. The exciting report on new oxazolidinone derivatives with potent activity against fastidious Gram-negative organisms is highlighted. Most of the new quinolones are structurally dissimilar to the traditional fluoroquinolones and demonstrate activity against Helicobacter pylori (MIC=0.013 microg/ml). New 14-membered macrolides with broad-spectrum activity including against Mycobacterium avium are also presented. A novel peptidic antibiotic with potent antimicrobial activity against Streptococcus pneumoniae (MIC<0.0005 microg/ml) is also highlighted.
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