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Curcumin Mitigates Gut Dysbiosis and Enhances Gut Barrier Function to Alleviate Metabolic Dysfunction in Obese, Aged Mice.
Biology (Basel)
November 2024
Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
The gut microbiome plays a critical role in maintaining gut and metabolic health, and its composition is often altered by aging and obesity. This study aimed to investigate the protective effects of curcumin on gut dysbiosis, gut barrier integrity, and bile acid homeostasis in aged mice fed a high-fat, high-sugar diet (HFHSD). Eighteen- to twenty-one-month-old male C57BL/6 mice were divided into groups fed a normal chow diet or HFHSD, with or without curcumin supplementation (0.
View Article and Find Full Text PDFBackground: Stone impaction is an obstacle to successful laparoscopic common bile duct exploration (LCBDE). This study aims to identify the incidence, operative difficulties and techniques used to disimpact and remove impacted stones during LCBDE.
Methods: Prospectively collected data from a large series of LCBDE.
NXT629 Ameliorates Cholesterol Gallstones in Mice Model by Improving Lipid Metabolism Disorder and Cholesterol Homeostasis Through Inhibiting the GPAM Pathway.
Dig Dis Sci
December 2024
Huadu District People's Hospital of Guangzhou, Huadu District, No. 48 Xinhua Road, Guangzhou, 510800, China.
Background: NXT629, a PPAR-alpha antagonist, exerts widespread effects in many diseases; however, its function and relevant mechanism in cholesterol gallstones (CG) remain largely unknown.
Methods: Male C57BL/6 J mice were fed a regular diet or lithogenic diet (LD), followed by treatment with intraperitoneal injection of NXT629. H&E staining was performed to analyze hepatic pathological changes, and Oil red O staining was conducted to detect lipid accumulation.
Detection frequency, sonoanatomy and reference values of the duodenal papillae and connected anatomical structures in cats.
J Small Anim Pract
December 2024
Tierklinik Düsseldorf GmbH, Düsseldorf, Germany.
Article Synopsis
- - The study aimed to evaluate the detection frequency and anatomy of the duodenal papillae and related structures in cats, using ultrasound on 50 cats.
- - The major duodenal papilla was detected in all cases, while the minor one appeared in 10%. Key dimensions of the anatomical structures were measured in clinically healthy cats.
- - Findings suggest that ultrasound exams of duodenal papillae are straightforward and can be an essential part of diagnosing conditions in feline patients.
Gut microbiome shifts in adolescents after sleeve gastrectomy with increased oral-associated taxa and pro-inflammatory potential.
medRxiv
September 2024
Clinical Microbiome Unit. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Background: Bariatric surgery is highly effective in achieving weight loss in children and adolescents with severe obesity, however the underlying mechanisms are incompletely understood, and gut microbiome changes are unknown.
Objectives: 1) To comprehensively examine gut microbiome and metabolome changes after laparoscopic vertical sleeve gastrectomy (VSG) in adolescents and 2) to assess whether the microbiome/metabolome changes observed with VSG influence phenotype using germ-free murine models.
Design: 1) A longitudinal observational study in adolescents undergoing VSG with serial stool samples undergoing shotgun metagenomic microbiome sequencing and metabolomics (polar metabolites, bile acids and short chain fatty acids) and 2) a human-to-mouse fecal transplant study.
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