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Epigenetic age across development in children and adolescents with ADHD.
Psychiatry Res
January 2025
Centre for Social and Early Emotional Development and School of Psychology, Deakin University, Burwood, Victoria, Australia; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. Electronic address:
Unlabelled: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition, though symptoms vary both within and between people in the population. We aimed to investigate trajectories of individual biological aging through the change in residuals of DNA methylation age estimates (EpiAge) regressed on chronological age (EpiAge Gap) in children and adolescents with and without ADHD.
Methods: Three well-established epigenetic clocks (PedBE, Horvath, and Skin & blood) were used to estimate EpiAge in 293 saliva samples from 169 participants (91 with ADHD symptoms) from the Neuroimaging of the Children's Attention Project (NICAP).
Generation Victoria (GenV): protocol for a longitudinal birth cohort of Victorian children and their parents.
BMC Public Health
January 2025
Murdoch Children's Research Institute, 50 Flemington Road, Parkville, VIC, 3052, Australia.
Background: In a world confronted with new and connected challenges, novel strategies are needed to help children and adults achieve their full potential, to predict, prevent and treat disease, and to achieve equity in services and outcomes. Australia's Generation Victoria (GenV) cohorts are designed for multi-pronged discovery (what could improve outcomes?) and intervention research (what actually works, how much and for whom?). Here, we describe the key features of its protocol.
View Article and Find Full Text PDFEstimation of Genetic Parameters and GWAS on Water Efficiency Traits in the Senepol Cattle.
J Anim Breed Genet
December 2024
Departament of Animal Science, Federal University of Viçosa, Viçosa, Brazil.
The need for producing in environmentally resilient system drives new research to achieve sustainable beef production. Water footprint of the beef supply chain is a concern that must be addressed, aiming to improve water use within the production chain. One approach is genetic selection of beef cattle for water efficiency.
View Article and Find Full Text PDFLongitudinal detection of somatic mutations in the saliva of head and neck squamous cell carcinoma-affected patients: a pilot study.
Front Oncol
November 2024
Department of Medicine (DMED), University of Udine, Udine, Italy.
Article Synopsis
- - Liquid biopsy is being researched as a method to improve the diagnosis and monitoring of head and neck squamous cell carcinoma (HNSCC), which has a high chance of recurrence after treatment.
- - A study with 17 patients analyzed saliva samples for genetic mutations, finding that a significant portion contained pathogenic variants, with TP53 being the most commonly mutated gene.
- - The findings suggest that analyzing salivary DNA could help in early detection of disease recurrence, paving the way for more personalized treatment options based on individual mutations.
Background: Ozonated water is expected to be an effective disinfectant for SARS-CoV-2 present on environmental fomites; however, ozone is consumed by organic substances, resulting in attenuation of its effect. SARS-CoV-2 present in saliva can contaminate environmental surfaces; therefore, it is essential to understand the effect of organic substances in saliva on the disinfectant properties of ozonated water.
Aim: To assess organic factors in saliva and the extent to which they diminish the effect of ozonated water on SARS-CoV-2.
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