Experiments designed to ascertain the effects of oxgen at 8, 10, and 12 psi partial pressure on the brains of pocket mice (Perognathus longimembris) were carried out at room temperature (24 degrees C, 75 degrees F) and at 32 degrees C (93 degrees F). The animals exposed to 8-12 psi at 32 degrees C had been in earlier KO2 oxygen tests. Five animals exposed either to 10 or 12 psi (517 mm or 620 mm HG) PO2 at 32 degrees C died during the course of the tests, possibly as a consequence of injury sustained by the earlier PO2 testing. Autopsy was not carried out. In the other 36 exposed animals, no pathological changes were observed in the brain. It is thus highly probable that oxygen pressures at the hyperbaric levels to which the pocket mice would be exposed during the Apollo XVII mission would not result in any lesions in the brain.

Download full-text PDF

Source

Publication Analysis

Top Keywords

pocket mice
16
degrees degrees
12
apollo xvii
8
animals exposed
8
degrees
6
effects cosmic
4
cosmic radiation
4
pocket
4
radiation pocket
4
mice
4

Similar Publications

Spiny pocket mice are usually divided into two genera, Heteromys and Liomys, and more recently the latter have been subsumed into the former, leaving subfamily Heteromyinae with one genus. However, this arrangement conveys false equivalency among heteromyines, and does not represent the great morphological, molecular, and ecological diversity in this subfamily. To address this, geometric morphometric methods were used to explore interspecific cranial variation in this subfamily, which were then evaluated in the context of recent phylogenetic and taxonomic findings.

View Article and Find Full Text PDF

The sulfur-related metabolic status of during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target.

Virulence

December 2025

Manchester Fungal Infection Group (MFIG), Division of Evolution, Infection, and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Sulfur metabolism is an essential aspect of fungal physiology and pathogenicity. Fungal sulfur metabolism comprises anabolic and catabolic routes that are not well conserved in mammals, therefore is considered a promising source of prospective novel antifungal targets. To gain insight into sulfur-related metabolism during infection, we used a NanoString custom nCounter-TagSet and compared the expression of 68 key metabolic genes in different murine models of invasive pulmonary aspergillosis, at 3 time-points, and under a variety of conditions.

View Article and Find Full Text PDF

Cigarette smoke components modulate the MR1-MAIT axis.

J Exp Med

February 2025

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Australia.

Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette smoke (CS) compromises immunity, yet little is known of the components of CS that impact T cell function. MR1 is a ubiquitous molecule that presents bacterial metabolites to MAIT cells, which are highly abundant in the lungs.

View Article and Find Full Text PDF

Ligand Design with Accelerated Disulfide Formation with Serum Albumin to Extend Blood Retention.

ACS Med Chem Lett

January 2025

Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan.

We proposed a novel ligand for the interaction with human serum albumin (HSA) to extend the blood half-life of small molecular weight therapeutics. The ligand features an alkyl chain and an activated disulfide to allow binding to the hydrophobic pockets of HSA and the formation of disulfide to Cys34 of HSA, thereby minimizing the initial renal clearance. The dual nature of the ligand-HSA bonding was expected to give the ligand long blood retention.

View Article and Find Full Text PDF

Structural analyses of Cryptosporidium parvum epitopes reveal a novel scheme of decapeptide binding to H-2K.

J Struct Biol

January 2025

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, PR China. Electronic address:

Cryptosporidium has gained much attention as a major cause of diarrhea worldwide. Here, we present the first structure of H-2K complexed with a decapeptide from Cryptosporidium parvum Gp40/15 protein (Gp40/15-VTF10). In contrast to all published structures, the aromatic residue P3-Phe of Gp40/15-VTF10 is anchored in pocket C rather than the canonical Y/F at P5 or P6 reported for octapeptides and nonapeptides.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!