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Synovial lipomatosis is an uncommon, intra-articular, fat-containing, proliferative lesion with unknown etiology that is rarely reported in dogs. A retrospective study spanning 13 years was conducted to search for cases of canine synovial lipomatosis. Among 188 synovial biopsies of major diarthrodial joints (ie, shoulder, elbow, carpus, hip, stifle, and tarsus) from 186 dogs, 4 cases (2.
View Article and Find Full Text PDFAdvances in the Treatment of Congenital Infiltrating Lipomatosis of the Face: The Role of PIK3CA Mutations and Microvascular Reconstruction.
J Craniofac Surg
January 2025
Department of Oral Maxillofacial Surgery, Walter Reed National Military Medical Center.
Congenital infiltrating lipomatosis of the face is a rare aggressive-benign disorder characterized by progressive hemifacial overgrowth and complex, often asymmetrical, facial differences. Recently linked with the PIK3CA-Related Overgrowth Spectrum, it arises from mosaic mutations in the PIK3CA gene. Treatment, largely supportive and tailored to individual clinical presentations, requires a multidisciplinary approach.
View Article and Find Full Text PDFConcurrent PIK3CA and IDH1 variants in facial infiltrating lipomatosis with intracranial lesions.
Genes Dis
March 2025
Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
An immortalized adipose-derived stem cells line from the -related overgrowth spectrum: Unveiling novel therapeutic targets.
Biochem Biophys Rep
December 2024
Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
PIK3CA-related overgrowth spectrum (PROS) encompasses several rare conditions that lead to overgrowth of various body parts resulting from activating variants in . The absence of ideal cell models significantly impedes progress in PROS research. In this study, we focused on facial infiltrating lipomatosis (FIL) (A disorder within PROS) and aimed to establish and characterize an immortalized PROS cell line.
View Article and Find Full Text PDFSynovial Lipomatosis in the Knee Joint: A Report of a Rare Condition.
Cureus
October 2024
Orthopedics, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, IND.
Article Synopsis
- Synovial lipomatosis is a rare, benign condition affecting the synovial lining of joints, primarily the knee, and is characterized by the presence of mature fat infiltrating the joint tissue, causing pain and swelling.
- It typically leads to joint movement restrictions and can occur in other joints like the hip and ankle, but diagnosis is often challenging due to its rarity and unclear causes.
- Treatment options range from conservative management to surgical intervention; in this case, a 47-year-old male underwent surgery for severe symptoms, including arthroscopic debridement and synovectomy.
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