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Methylation Profiles Differ According to Clinical Characteristics in Well-Differentiated Neuroendocrine Tumors of the Lung.
Endocr Pathol
March 2025
Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Neuroendocrine tumors (NET) of the lung constitute a rare entity of primary lung malignancies that often exhibit an indolent clinical course. Epigenetics-related differences have been described previously for lung NET, but the clinical significance remains unclear. In this study, we performed genome-wide methylation analysis using the Infinium MethylationEPIC BeadChip technology on FFPE tissues from lung NET treated at two academic centers.
View Article and Find Full Text PDFSomatic Malignancies Arising in Ovarian Mature Cystic Teratomas: A Multi-Institutional Study of 40 Cases Highlighting Outcomes and Novel Malignancies.
Am J Surg Pathol
March 2025
Department of Pathology and Laboratory Sciences, UC Davis Medical Center, Sacramento, CA.
Somatic malignancy arising in ovarian mature cystic teratoma (MCT) is a relatively rare phenomenon with an estimated incidence ranging from 0.17% to 5.5%.
View Article and Find Full Text PDFClinical, pathological characteristics, and therapeutic outcomes of primary ovarian carcinoid tumors: a case series of 15 cases.
World J Surg Oncol
March 2025
Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, No.2, Fuxue Lane, Lucheng District, Wenzhou, 325000, Zhejiang, China.
Background: The exact characteristics of primary ovarian carcinoid tumors remain largely unknown because of the rarity of the cases. This study aimed to investigate the clinical features, pathological characteristics, and therapeutic outcomes of patients with primary ovarian carcinoid tumors.
Methods: This retrospective case series included patients with primary ovarian carcinoid tumors diagnosed between January 2009 and December 2023 at the First Affiliated Hospital of Wenzhou Medical University.
This review covers current classification systems and the knowledge of genetic disorders and medical therapies. Thymic carcinoids or neuroendocrine neoplasms (t-NEN) are a rare entity with dismal prognosis. About 25% of the tumors are related to Multiple Endocrine Neoplasia type I (MEN-1), where they contribute significantly to mortality.
View Article and Find Full Text PDFThe Influence of the Clinical, Therapeutic and Socio-Personal Profile on the Quality of Life of Patients With Multiple Endocrine Neoplasia Type 1.
World J Surg
March 2025
Endocrine Surgery Unit, General Surgery Service, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
Introduction: Multiple endocrine neoplasia type 1 (MEN1) syndrome is characterized by presenting different pathologies with different degrees of tumor aggressiveness, which can greatly affect the quality of life of affected patients.
Objectives: To determine the quality of life of MEN1 patients and to analyze the influence of socio-personal, clinical, and therapeutic variables.
Methods: A study was conducted on MEN1 patients in a tertiary hospital [2018-2020].
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