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The protein segregase VCP/p97 promotes host antifungal defense via regulation of SYK activation.
PLoS Pathog
October 2024
Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Immunity and Infection, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, P. R. China.
C-type lectin receptors (CLRs) are essential to execute host defense against fungal infection. Nevertheless, a comprehensive understanding of the molecular underpinnings of CLR signaling remains a work in progress. Here, we searched for yet-to-be-identified tyrosine-phosphorylated proteins in Dectin-1 signaling and linked the stress-response protein valosin containing protein (VCP)/p97 to Dectin-1 signaling.
View Article and Find Full Text PDFEfficacy of Intralesional Candida Injection in the Treatment of Cutaneous Warts: A Systematic Review and Meta-Analysis.
Acta Derm Venereol
October 2024
Research Center of Big Data and Meta-analysis, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Recent studies that examined the treatment efficacy of Candida antigen injection for both non-genital and genital warts yield inconsistent results. To address this, a systematic review and meta-analysis was conducted, comparing the treatment response between Candida antigen injection therapy and other intralesional immunotherapies across all types of warts. PubMed, Cochrane Library, and Embase were searched for relevant randomized controlled trials (RCTs) from inception to 16 September 2023, and 24 eligible RCTs were identified.
View Article and Find Full Text PDFUnveiling the Innate and Adaptive Immunity Interplay: Global Transcriptomic Profiling of the Host Immune Response in Endophthalmitis in a Murine Model.
ACS Omega
October 2024
Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad 500034, Telangana, India.
Intraocular fungal infection poses a significant clinical challenge characterized by chronic inflammation along with vision impairment. Understanding the host defense pathways involved in fungal endophthalmitis will play a pivotal role in identifying adjuvant immunotherapy. Clinical isolates of (15,000 CFU/μL) were intravitreally injected in C57BL/6 mice followed by enucleation at 24 and 72 h postinfection.
View Article and Find Full Text PDFCandidiasis in breast cancer: Tumor progression or not?
Iran J Basic Med Sci
January 2024
Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.
Article Synopsis
- Candidiasis is a fungal infection that can thrive in cancer patients, potentially worsening their condition and promoting cancer progression.
- The review focuses on how this fungus affects cancer, particularly breast cancer, by generating harmful substances and influencing immune responses.
- It highlights the need for better antifungal treatments specifically designed for immunocompromised patients, aiming to manage infections while considering their cancer treatment.
FcRider: a recombinant Fc nanoparticle with endogenous adjuvant activities for hybrid immunization.
Antib Ther
October 2024
Antagen Pharmaceuticals, Inc., Canton, MA 02021, United States.
Article Synopsis
- Active immunization provides long-lasting immunity but takes time to develop, while passive immunization offers immediate protection but is short-lived and costly.
- Researchers created a nanoparticle called "FcRider," engineered from a human IgG1 fragment, which is stable, easy to produce, and has its own immune-boosting properties.
- FcRider can combine benefits of both active and passive immunizations, showing promise in generating strong immune responses and potentially advancing cancer treatments.
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