The study was performed in 25 kidneys of people who died from mechanic asphyxia and craniocerebral trauma and in 56 of those who died from cardiovascular diseases (hypertensive disease, chronic ischemic heart disease and their combination) with the use of histochemic, morphometric and variational statistic methods. It was established that in cardiovascular diseases studied ATPase and alkaline phosphatase activity increased in vessels mainly in juxtamedullary zone of the kidneys substantia alba. The enzymatic activity changes studied are obviously connected with the functional load increase at this zone of kidneys and the juxtaglomerular shunt reinforcement. This process can be regarded as the display of compensatory adaptive reactions morphochemical equivalent.

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